低分子肝素预防人工髋关节置换术后下肢深静脉血栓形成的疗效

Effect of low molecular weight heparin on preventing deep venous thrombosis of lower extremities after artificial hip replacement

目的分析低分子肝素应用于人工髋关节置换术后对患者下肢深静脉血栓形成的临床效果。方法按照入院先后顺序将2014年4月至2016年5月100例接受人工髋关节置换术的患者分为两组,每组50例。对照组患者给予常规治疗,观察组患者在此基础上给予低分子肝素治疗,比较两组患者的疗效与不良反应发生情况。结果观察组患者的下肢深静脉血栓的发生率为4.0%,明显低于对照组的22.0%,差异具有统计学意义(P<0.05);观察组患者的不良反应发生率为2.0%,明显低于对照组的14.0%,差异具有统计学意义(P<0.05)。结论低分子肝素可有效预防人工髋关节置换术后患者下肢深静脉血栓的形成,且安全性高,应在临床推广应用。

Objective To analyze lhe clinical effecl of low molecular weighl heparin on lower limb deep venous lhrombosis afler arlificial hip replacemenl. Methods According lo lhe order of admission, 100 cases of palienls underwenl arlificial hip replacemenl from April 2014 lo May 2016 were divided inlo conlrol group and observalion group, wilh 50 palienls in each group. The conlrol group was lrealed wilh rouline lherapy, while lhe observalion group was given low molecular weighl heparin on lhis basis, lhe curalive effecls and adverse reaclions in lhe lwo groups were compared. Results The incidence of deep vein lhrombosis in lhe observalion group was 4.0%, which was significanlly lower lhan 22.0% in lhe conlrol group, lhe difference was slalislically significanl （ P〈0.05）. The incidence of adverse reaclions in lhe observalion group was 2.0% , which was significanlly lower lhan 14.0% in lhe conlrol group, lhe difference was slalislically significanl （ P〈0.05）. Conclusion Low molecular weighl heparin can effeclively prevenl lhe formalion of deep venous lhrombosis of lower limbs afler arlificial hip replacemenl, and il has higher safely, which should be applied in clinical.