N-端脑利钠肽前体检测对心力衰竭患者的诊断价值分析

Analysis of diagnostic value of NT-proBNP detection on patients with heart failure

目的探讨N-端脑利钠肽前体(NT-proBNP)检测对心力衰竭的诊断价值。方法选择2012年6月至2016年6月我院收治的心力衰竭患者532例作为研究组,将同期52例有心衰症状但非心衰患者作为对照组,测定两组患者血清中NT-proBNP水平,比较两组患者血清NT-proBNP水平和不同等级心力衰竭患者的NT-proBNP水平。结果研究组NT-proBNP水平明显高于对照组(P<0.05);不同等级心力衰竭患者的NT-proBNP水平比较为Ⅳ级>Ⅲ级>Ⅱ级>Ⅰ级(P<0.05);Pearson相关性分析显示,心衰患者血清NT-proBNP水平与NYHA心功能分级呈正相关(r=0.73,P=0.031)。结论 NT-proBNP水平与心力衰竭程度密切相关,可作为心力衰竭诊断的重要指标,对判断患者心衰程度及预后评估具有重要指导意义。

Objective To investigate the diagnosis value of NT-proBNP detection on patients with heart failure. Methods Five hundred and thirty-two cases of patients with heart failure in our hospital from June 2012 to June 2016 were selected as the research group, and 52 cases of patients with heart failure symptom but not heart failure in the same period as the control group. The levels of serum NT-proBNP in the two groups were detected and compared, and that of patients with different grade heart failure were also compared. Results The level of NT-proBNP in the research group was higher than that of the control group（P〈0.05）. The NT-proBNP level of different grades heart failure patients were grade Ⅳ〉grade Ⅲ〉grade Ⅱ〉grade Ⅰ（P〈0.05）. Pearson correlation analysis showed that the NT-proBNP level was positively related with cardiac function classification phase（r=0.73,P=0.031）. Conclusion NT-proBNP level is closely related to the degree of heart failure, which could be a important index in the diagnosis of heart failure, and has a important guiding significance to judge degree of heart failure and assess prognosis.