阿托伐他汀钙片联合氨氯地平治疗高血压合并冠心病30例临床分析

Clinical analysis of atorvastatin calcium combined with amlodipine on 30 cases of patients with hypertension combining coronary heart disease

目的观察阿托伐他汀钙联合氨氯地平治疗高血压合并冠心病的临床效果。方法将60例高血压合并冠心病患者随机分为对照组和观察组,每组30例。对照组单用氨氯地平治疗,观察组给予阿托伐他汀钙联合氨氯地平治疗,比较两组患者的治疗效果及安全性。结果观察组舒张压控制总有效率达96.67%,显著高于对照组的80.00%(P<0.05)。观察组心绞痛总有效率达93.33%,显著高于对照组的73.33%(P<0.05)。观察组心电图治疗总有效率达93.33%,显著高于对照组的70.00%(P<0.05)。观察组硝酸甘油用量明显低于对照组(P<0.05),但两组不良反应发生率无显著差异(P>0.05)。结论阿托伐他汀钙联合氨氯地平治疗高血压合并冠心病临床效果优于单用氨氯地平治疗,值得临床推广应用。

Objective To observe the effect of atorvastatin calcium combined with amlodipine on hypertension combining coronary heart disease. Methods Sixty cases of patients with hypertension combining coronary heart disease were randomly divided into control group and observation group, with 30 cases in each group. The control group received amlodipine alone,while the observation group was given atorvastatin calcium combined with amlodipine. The treatment effect and safety were compared in the two groups. Results The total effective rate of diastolic blood pressure control in the observation group was96.67%, which was significantly higher than 80.00% of the control group（P〈0.05）; the total effective rate of angina pectoris was 93.33% in the observation group, which was significantly higher than 73.33% of the observation group（ P〈0.05）; the total effective rate of electrocardiogram was 93.33% in the observation group, which was significantly higher than 70.00%in the control group（P〈0.05）; the amount of nitroglycerin in the observation group was significantly lower than that of the control group（P〈0.05）, but there was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Atorvastatin calcium combined with amlodipine on hypertension combining coronary heart disease has better clinical effect, which is worthy of clinical popularization and application.