IL-17、IgE在支气管哮喘患儿血清中的浓度变化及其临床意义

Concentration changes and clinical significance of IL-17, IgE in serum in children with bronchial asthma

目的探讨支气管哮喘患儿IL-17、IgE的浓度变化与其病情轻重程度的相关性。方法将支气管哮喘急性期患儿(27例)和经吸入性糖皮质激素治疗后临床症状得到缓解的急性期患儿(36例)分别作为哮喘急性期组和急性缓解期组。检测两组患儿外周血清中IL-17、IgE含量和NEU、EOS及LYM的数量,并分析其与IL-17、IgE表达水平的相关性。结果哮喘急性期组与急性缓解期组的IgE、NEU、EOS及LYM数量比较,差异显著(P<0.05)。急性缓解期患儿NEU、EOS及LYM数量与IL-17水平有显著相关性(P<0.05)。治疗后,急性期组哮喘患儿血清中IL-17与IgE、NEU及LYM的数量均呈正相关(P<0.05)。结论IL-17、IgE可能参与了支气管哮喘的发病机制,可作为判断患儿病情的理论依据。

Objective To investigate the correlation between the changes of IL-17 and IgE levels and the severity of asthma in children with bronchial asthma. Methods Twenty-seven children with bronchial asthma in acute stage were selected as the acute phase of asthma group, and the inhaled corticosteroids after clinical remission of acute bronchiolitis（36cases） were selected as the acute remission group. The contents of IL-17, IgE and numbers of NEU, EOS and LYM in peripheral blood of the two groups were detected, and the correlation with IL-17 and IgE expression were analyzed.Results The IgE level, numbers of NEU, EOS and LYM of the two group had significant difference（P〈0.05）. There were significant correlation between numbers of NEU, EOS, LYM and IL-17 level in the acute remission group（P〈0.05）. After treatment, IL-17 in the acute phase of asthma group was significantly correlated with IgE, NEU, EOS and LYM（P〈0.05）.Conclusion IL-17 and IgE may be involved in the pathogenesis of bronchial asthma, which can be used as a theoretical basis for judging the condition of the children.