不同质子泵抑制剂疗法治疗87例胃溃疡患者临床疗效观察

Clinical effect observation of different proton pump inhibitor therapys in 87 patients with gastric ulcer

目的观察分析不同质子泵抑制剂治疗胃溃疡的临床疗效。方法选取我院收治的87例胃溃疡患者作为研究对象,根据患者入院就诊先后顺序分为甲、乙、丙三组,各29例,分别应用奥美拉唑、泮托拉唑、雷贝拉唑进行治疗,比较三组患者的临床疗效及不良反应发生情况。结果甲、乙、丙三组患者的临床总有效率分别为96.55%、93.10%、96.55%,三组比较,差异无统计学意义(P>0.05);三组患者的不良反应总发生率分别为6.90%、27.59%、31.03%,甲组与乙、丙组组间比较,差异有统计学意义(P<0.05)。结论奥美拉唑治疗胃溃疡的疗效及安全性较佳,有利于患者的机体恢复。

Objective To observe the clinical effects of different proton pump inhibitors in the treatment of gastric ulcer.Methods Eighty-seven cases of gastric ulcer patients in our hospital were selected as the research objects, which were divided into A, B, C group according to the order of admission successively, with 29 cases in each group, the patients in A,B, C group received omeprazole, pantoprazole and rabeprazole respectively, then the clinical curative effects and adverse reactions of the three groups were compared. Results The clinical total effective rate of A, B, C group were 96.55%,93.10% and 96.55% respectively, the differences among the three groups were not significant（P〉0.05）; the incidence rate of adverse reactions of the three groups were 6.90%, 27.59% and 31.03% respectively, the A group was significantly lower than that of the B, C group（P〈0.05）. Conclusion The curative effect and safety of omeprazole in the treatment of gastric ulcer is good, and conducive to the recovery of the patients.