高分辨率CT(HRCT)半定量诊断慢性阻塞性肺疾病的临床效果

Clinical effect of high resolution CT semi-quantitative diagnosis of chronic obstructive pulmonary disease

目的探讨高分辨率CT(HRCT)半定量诊断慢性阻塞性肺疾病(COPD)的临床效果。方法对临床诊断为COPD的60例患者全部进行HRCT检查,根据目测HRCT上低衰减区占肺野的比例不同分为A组(<50%)和B组(≥50%),各30例。治疗3周后进行疗效评定,比较两组患者的肺功能指标、住院期间并发症发生率和死亡率。结果治疗3周后,A组患者的VC、TLC、FEV1、FEV1/FVC及DLCO水平均高于治疗前(P<0.05);B组患者的FEV1、FEV1/FVC水平高于治疗前(P<0.05);A组患者的并发症发生率、死亡率和住院天数均优于B组(P<0.05)。结论 HRCT半定量诊断能评估COPD的临床治疗效果,有一定的临床指导意义。

Objective To investigate the clinical therapeutic effects of high resolution CT（HRCT） semi quantitative diagnosis on chronic obstructive pulmonary disease（COPD）. Methods Sixty cases of patients with COPD were divided into group A（〈50%） and group B（≥50%） according to the proportion of low attenuation area in the HRCT, with 30 cases in each group. After 3 weeks of treatment, the efficacy of the two groups of patients with lung function indicators, hospital complications and mortality during hospitalization were compared. Results After 3 weeks treatment, the VC, TLC, FEV1,FEV1/FVC and DLCO of the group A were significantly better than those before treatment（P〈0.05）; the FEV1/FVC, FEV1 of the group B after treatment were significantly better than those before treatment（P〈0.05）; the incidence rate of complications,mortality, hospital days in the group A were significantly superior to those of the group B（P〈0.05）. Conclusion HRCT semi quantitative diagnosis can evaluate the clinical therapeutic effect of COPD, which has some clinical guiding significance.