丁苯酞联合高压氧对急性脑梗死患者认知功能障碍的影响

Effect of butylphthalide combined with hyperbaric oxygen on cognitive dysfunction in patients with acute cerebral infarction

目的探讨丁苯酞联合高压氧对脑梗死后认知功能障碍的治疗效果。方法抽取我院收治的90例急性脑梗死伴有认知功能障碍患者,随机分成观察组和对照组,各45例。对照组采用常规治疗,观察组在常规治疗基础上加用丁苯酞联合高压氧治疗,对比两组治疗前、后MMSE及ADL评分。结果治疗后,观察组与对照组MMSE量表总分及ADL总分与治疗前比较,明显改善(P<0.05),且观察组明显优于对照组(P<0.05);两组患者MMSE量表中时间定向、地点定向、语言即刻记忆、注意和计算、短程记忆以及言语表达评分明显提高,且观察组明显高于对照组(P<0.05);两组患者ADL量表中躯体生活能力及工具使用能力评分均明显降低,且观察组明显低于对照组(P<0.05)。结论丁苯酞联合高压氧治疗对脑梗死患者认知功能的改善、神经功能的恢复疗效显著。

Objective To investigate the therapeutic effect of butylphthalide combined with hyperbaric oxygen on cognitive dysfunction after cerebral infarction. Methods Nighty cases of acute cerebral infarction patients with cognitive dysfunction were selected and divided into observation group and control group, with 45 cases in each group. The control group accepted routine treatment; on this basis, the observation group was treated with butylphthalide combined with hyperbaric oxygen; then the MMSE and ADL scores before and after treatment were compared between the two groups. Results After treatment, the total scores of MMSE and ADL in the two groups significantly improved compared with before treatment （P〈0.05）, and those in the observation group were significantly superior to the control group （P〈0.05）. There were significant differences in the time orientation, location orientation, language immediate memory, attention and calculation, short-range memory, and verbal expression scores in the MMSE scale of the two groups （P〈0.05）, and the scores of the observation group were higher than the control group （P〈0.05）; the scores of physical capacity and tool use ability of ADL scale in both groups decreased, and those of the observation group were lower than the control group （P〈0.05）. Conclusion Butylphthalide combined with hyperbaric oxygen therapy has significant effect in the improvement of cognitive function and the recovery of neurological function.