多索茶碱联合布地奈德治疗支气管哮喘的效果

Clinical effect of doxofylline combined with budesonide on bronchial asthma

目的探讨多索茶碱联合布地奈德治疗支气管哮喘的效果及不良反应。方法选取我院2014年2月至2017年1月收治的38例支气管哮喘患者作为研究对象,将其随机分为A组与B组,各19例,A组给予布地奈德雾化吸入治疗,B组在A组的基础上给予多索茶碱静脉滴注治疗,并观察两组患者的血清C-反应蛋白(CRP)、血沉(ESR)、痰液嗜酸性粒细胞(EOS)、肺功能指标、临床疗效及不良反应发生率。结果治疗后,两组支气管哮喘患者的血清CRP、血清ESR和痰液Eos均明显下降,且B组显著低于A组(P<0.05);治疗后,两组支气管哮喘患者的FVC、FEV1、FEV1%和PEF水平均明显升高,且B组显著高于A组(P<0.05);B组患者的治疗总有效率为94.74%,不良反应总发生率为5.26%,均明显优于A组的63.16%、36.84%(P<0.05)。结论多索茶碱联合布地奈德治疗支气管哮喘的效果显著,不良反应较小,值得在临床中推广实施。

Objective To invesligale the effecl and adverse reactions of doxofylline combined with budesonide on bronchial asthma. Methods Thirly-eighl palienls with bronchial asthma who admitted in our hospital from February 2014 lo January 2017 were selected as the subjects and divided into group A and group B, with 19 cases in each group. The group Awas treated with inhalation of budesonide, and group B was given intravenous drip of doxofylline on lhe basis of group A. The levels of serum C-reaclive protein （ CRP）, erylhrocyle sedimentation rale （ ESR）, sputum eosinophils （ EOS）, lung function, clinical efficacy and incidence of adverse reactions were compared between lhe lwo groups of palienls. Results After treatment, lhe levels of serum CRP, serum ESR and sputum EOS in lhe lwo groups declined obviously, and those in lhe group B were lower than lhe group A （ P〈0.05）. After treatment, lhe levels of FVC, FEY1, FEY1% and PEF in lhe lwo groups increased obviously, and those in lhe group B were higher than lhe group A （ P〈0.05）. The lolal effective rale and incidence rale of adverse reactions in lhe group B were 94.74% and 5.26% respectively, which were belter than 63.16%, 36.84% in lhe group A （ P〈0.05）. Conclusion Doxofylline combined with budesonide in treatment of bronchial asthma has significant effecl, with less adverse reactions, which is worthy of clinical promotion and application.