血清脂蛋白(a)与C反应蛋白在尿毒症血液透析患者中的变化及意义

Changes and significance of serum lipoprotein(a) and C-reactive protein in patients with uremic hemodialysis

目的探讨尿毒症血液透析患者治疗中血清脂蛋白(a)与C反应蛋白的变化及意义。方法选取2015年4月至2016年4月本院收治的尿毒症血液透析患者52例为研究组;选取同期本院体检的52名健康人为对照组。比较两组患者血清脂蛋白(a)[Lp(a)]、C反应蛋白(CRP)、尿素氮和血清肌酐检测结果。结果研究组透析后血清Lp(a)、CRP、尿素氮、血清肌酐水平均高于对照组,且研究组透析后血清Lp(a)与CRP水平均明显低于透析前(P<0.05);研究组血清Lp(a)与CRP呈现正相关(P<0.05),与血肌酐、尿素氮无相关性(P>0.05)。结论应加强尿毒症血液透析患者血清Lp(a)与CRP水平检测,尽早采取积极措施进行治疗,以减少心脑血管事件的发生。

Objective To invesligale the changes and significance of serum lipoprolein （ a） and C reactive protein in palienls with uremic hemodialysis. Methods From April 2015 lo April 2016, 52 cases palienls with uremic hemodialysis admitted in our hospilal were selected as lhe study group, and 52 healthy people with physical examination in our hospilal in lhe same period were selected as lhe control group. The serum lipoprolein （ a） [ Lp（ a）], C reactive protein （ CRP）, urea nitrogen and serum creatinine were compared between lhe lwo groups. Results After hemodialysis, lhe levels of serum Lp（ a）, CRP, urea nitrogen and serum creatinine in study group were obviously higher than those in lhe control group （ P〈0.05）. After hemo dialysis, lhe levels of serum Lp（ a） and CRP in study group were significantly lower than those before dialysis （ P〈0.05）. In lhe study group, there was positive correlation between serum Lp（ a） and CRP （ P〈0.05）, bul no correlation with serum creatinine and urea nitrogen （ P〉^.05）. Conclusion To reduce lhe occurrence of cardiovascular events, lhe levelsof serum Lp（ a ） and CRP ofpalienls with uremia should be delected timely, and lhe treatment should be implemented as soon as possible.