针刺对痰湿壅盛型原发性高血压患者hs-CRP、IL-6的影响

Effect of Acupuncture on hs-CRP and IL-6 in Patients with Primary Hypertension Due to Excessive Retention of Dampness-heat

目的观察针刺对痰湿壅盛型Ⅰ级原发性高血压患者血管炎性因子超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平的影响,探讨炎性因子与血压变化的关系。方法将60例痰湿壅盛型Ⅰ级原发性高血压患者随机分为治疗组和对照组,每组30例。治疗组采用辨证取穴针刺治疗,对照组采用非经非穴针刺治疗,共治疗18次。比较两组治疗前后24 h动态血压及血清hs-CRP、IL-6水平的变化情况。结果治疗组治疗后24 h平均SBP、DBP与同组治疗前比较,差异均具有统计学意义(P<0.01)。两组治疗后24 h平均SBP、DBP比较,差异均具有统计学意义(P<0.05)。两组治疗后血清hs-CRP及IL-6水平虽有所下降,但与同组治疗前比较,差异均无统计学意义(P>0.05)。结论针刺是一种治疗痰湿壅盛型原发性高血压的有效方法,其机制可能与血清hs-CRP、IL-6炎症因子水平的下降有关。

Objective To observe the effect of acupuncture on the levels of hypersensitive C-reactive protein （hs-CRP） and interleukin-6 （IL-6） in patients with grade Ⅰ primary hypertension due to excessive retention of dampness-heat, and discuss the relationship between inflammatory factors and the change of blood pressure. Method Sixty patients with grade Ⅰ primary hypertension due to excessive retention of dampness-heat were randomized into a treatment group and a control group, 30 cases each. The treatment group was intervened by acupuncture with points selected based on syndrome differentiation, and the control group was treated with acupuncture at non-meridian points, for 18 sessions in total. The 24-hour ambulatory blood pressure, and serum hs-CRP and IL-6 levels were compared before and after the treatment. Result After the treatment, the 24-hour systolic blood pressure （SBP） and diastolic blood pressure （DBP） were significantly changed in the treatment group （P〈0.01）. There were significant differences in comparing the 24-hour SBP and DBP between the two groups after the treatment （P〈0.05）. The serum hs-CRP and IL-6 levels dropped after the treatment in both groups but without statistical significances （P〉0.05）. Conclusion Acupuncture is an effective approach in treating primary hypertension due to excessive retention of dampness-heat, and its action mechanism may be associated with the decrease of serum hs-CRP and IL-6 levels.