针药并用治疗咳嗽变异性哮喘疗效观察

Therapeutic Observation of Acupuncture plus Medication for Cough Variant Asthma

目的观察针刺配合内服自拟中药汤剂治疗咳嗽变异性哮喘的临床疗效。方法将62例咳嗽变异性哮喘患者随机分为治疗组32例和对照组30例。治疗组采用针刺配合内服自拟中药汤剂治疗,对照组采用口服孟鲁司特纳片治疗。治疗3个疗程后,观察两组治疗前后咳嗽积分、嗜酸性粒细胞计数(EOS)水平及肺功能各项指标[最高呼气流速(PEF)值、用力肺活量(FVC)、第1秒最大用力呼气量(FEV1)]的变化情况,并比较两组临床疗效。结果两组治疗后咳嗽积分、EOS水平及肺功能各项指标(PEF、FVC、FEV1)与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后咳嗽积分、EOS水平及肺功能各项指标与对照组比较,差异均具有统计学意义(P<0.05,P<0.01)。治疗组总有效率为93.8%,对照组为80.0%,两组比较差异具有统计学意义(P<0.05)。结论针刺配合内服自拟中药汤剂是一种治疗咳嗽变异性哮喘的有效方法。

Objective To observe the clinical efficacy of acupuncture plus oral administration of self-made Chinese herbal decoction in treating cough variant asthma （CVA）. Method Sixty-two CVA patients were randomized into a treatment group of 32 cases and a control group of 30 cases. The treatment group was intervened by acupuncture plus oral administration of self-made Chinese herbal decoction, and the control group was intervened by Montelukast sodium tablets. Before and after 3 courses of treatment, the score of cough, eosinophil （EOS） count, pulmonary function tests [peak expiratory flow （PEF）, forced vital capacity （FVC）, and forced expiratory volume in 1 second （FEV1）] were observed. The clinical efficacies were compared between the two groups. Result After the treatment, the score of cough, EOS count, and pulmonary function tests （PEF, FVC, and FEV1） were changed significantly in both groups （P〈0.05）. The score of cough, EOS level and pulmonary function tests in the treatment group were significantly different from those in the control group after the treatment （P〈0.05,P〈0.01）. The total effective rate was 93.8% in the treatment group versus 80.0% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion Acupuncture plus oral administration of self-made Chinese herbal decoction is an effective method in treating CVA.