苯磺酸左旋氨氯地平治疗原发性高血压的临床效果

Clinical effect of levamlodipine besylate in the treatment of essential hypertension

目的综合分析苯磺酸左旋氨氯地平在原发性高血压患者冶疗中的临床效果及对血流动力学的影响。方法选取于2014年12月~2016年12月在我院收治的156例原发性高血压患者,按照入院顺序随机分为实验组(应用苯磺酸左旋氨氯地平治疗方法,78例)与对照组(应用苯磺酸氨氯地平治疗方法,78例)。采用SPSS20.0统计学软件进行统计学分析两组患者的临床治疗总有效率、治疗前后的舒张压(DBP)、收缩压(SBP)以及血流动力学指标(全血低切还原黏度、红细胞聚集指数以及血浆黏度等)。结果 (1)实验组治疗总有效率为91.03%(71/78),对照组治疗总有效率为89.74%(70/78),两组患者的临床治疗总有效率比较无统计学意义(P>0.05);(2)治疗前,两组患者的DBP、SBP水平比较差异无统计学意义(P>0.05);治疗后,实验组患者的DBP、SBP水平较显著优于对照组(P<0.05);(3)实验组患者全血低切还原黏度、红细胞聚集指数以及血浆黏度水平显著优于对照组(P<0.05)。结论苯磺酸左旋氨氯地平在原发性高血压患者中的临床效果显著,有效改善血流动力学指标。

Objective To analyze the clinical effect of levamlodipine besylate in the treatment of patients with essential hypertension and its effect on hemodynamics. Methods A total of 156 patients with essential hypertension who were ad-mitted to our hospital from December 2014 to December 2016 were selected. According to the order of admission, the patients were randomly divided into experimental group （application of levamlodipine besylate, 78 cases） and control group （application of amlodipine besylate, 78 cases）. SPSS20.0 statistical software was used for statistical analysis of both groups on the total effective rate of clinical treatment, diastolic blood pressure （DBP）, systolic blood pressure （SBP） and hemodynamic parameters （whole blood low shear reduction viscosity, erythrocyte aggregation index and plasma vis-cosity） before and after treatment. Results （1） The total effective rate was 91.03% （71/78） in the experimental group, and the total effective rate was 89.74%（70/78） in the control group. There was no statistically significant difference in the total effective rate of clinical treatment between the two groups（P〉0.05）; （2） before treatment, the levels of DBP and SBP in the two groups were not statistically significant （P〉0.05）; after treatment, the levels of DBP and SBP in the ex-perimental group were significantly better than those in the control group（P〈0.05）;（3） the low blood shear reduction vis-cosity, erythrocyte aggregation index and plasma viscosity in the experimental group were significantly better than those in the control group（P〈0.05）. Conclusion The clinical effect of levamlodipine besylate in the patients with essential hy-pertension is significant, and the hemodynamic parameters can be improved effectively.