肿瘤坏死因子-α抑制剂对类风湿关节炎患者血清高密度脂蛋白水平的影响

Effect of TNF-α Inhibitor on the Level of Serum High Density Lipoprotein in Patients with Rheumatoid Arthritis

目的:观察肿瘤坏死因子-α(TNF-α)抑制剂对类风湿关节炎患者血清中高密度脂蛋白(HDL)水平的影响。方法:将43例类风湿关节炎患者分为治疗组23例和对照组20例。治疗组采用甲氨蝶呤联合TNF-α抑制剂治疗,对照组采用甲氨蝶呤治疗。检测2组治疗前及治疗2周、3个月后血清HDL水平。结果:治疗2周后治疗组HDL水平较治疗前升高(P<0.01),但治疗3个月后HDL水平较治疗前无明显变化(P>0.05)。对照组治疗2周后和3个月后HDL水平较治疗前均无明显变化(P>0.05)。结论:TNF-α抑制剂治疗能短暂性升高类风湿关节炎患者血清HDL水平。

Objective：To observe the effect of TNF-α inhibitor on the level of serum high density lipoprotein in patients with rheumatoid arthritis.Methods：Forty three patients with rheumatoid arthritis were divided into a treatment group（23 cases）and a control group（20 cases）.The treatment group was treated with methotrexate combined with TNF-α inhibitor,and the control group was treated with methotrexate.Serum HDL levels of the two groups were measured respectively before treatment and two weeks and three months after treatment.Results：After two weeks of treatment,the level of HDL in the treatment group was higher than that before treatment（P 〈 0.01）,but three months after treatment,the level of HDL had no signifcant change compared with that before treatment（P 〉 0.05）.After two weeks and three months of treatment,the level of HDL in the control group had no signifcant changes compared with before treatment（P 〉 0.05）.Conclusion：TNF-α inhibitors can transiently increase serum HDL levels in patients with rheumatoid arthritis.