液相贝克曼重排反应催化剂的研究进展

Research Progress on Liquid Beckmann Rearrangement Catalysts

Beckmann重排反应是指酮肟在酸催化下,发生分子内重排,生成相应的酰胺的反应,是有机和药物合成中的重要方法之一。但传统方法需使用大量的强酸催化剂,对环境的污染和设备的伤害较大。本文主要对近年来应用于液相Beckmann反应中的绿色催化剂,如新型无机Lewis酸催化剂、有机化合物类催化剂、离子液体催化剂以及其他催化体系等进行了综述。

The Beckmann rearrangement is one of the important methods in the synthesis of organic and pharmaceutical products by the reaction of the intramolecular rearrangement of ketoximes catalyzed by the acid. But the traditional method uses a lot of strong acid catalysts, which does harm to the environment the equipments. Green catalysts such as the new type of inorganic Lewis acid catalysts, organic compound catalysts, ionic liquid catalysts and other catalytic systems were commented.