家兔体内呋喃苯胺酸的药动学和药效学结合模型

Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits

用药动学-药效学结合模型对呋喃苯胺酸在家兔体内的处置和效应动力学作定量分析。呋喃苯胺酸的k_(eo),S,E_(max),EC_(50)分别为0.131±0.029min^(-1),2.21±0.61,6.5±0.6ml/min,3.49±0.77μg/ml。结果表明血浆与作用部位属于不同的房室,两者之间存在着一个平衡过程。

The pharmacokinetic and pharma codynamic profiles of furosemide were analyzed by the combined pharmacokinetic and pharmacodynamic model in rabbits. The pharmacodynamic parameters keo(the elimination rate constant of the effect compartment), S(Hill coefficient), EC50(the drug concentration at helf maximum effect), Emax(the maximum drug effect) for furosemide ((x|-)±SD) were 0.131±0.029 min-', 2.2±0.6, 3.5±μ0.8 μg/ml, and 6.5±0.6 ml/min, respectively. Following an iv dose offurosemide, its maximal diuretic effect occurred after the peak plasma concentration. This indicates that the plasma and effect site belong to different compartments and the equilibrium between the plasma and effect site does not reach instantaneously.