硫辛酸治疗灼口综合征的临床效果

Clinical effect of lipoic acid in burning mouth syndrome

目的探讨硫辛酸治疗灼口综合征的临床疗效。方法收集灼口综合征患者29例,分为2组,硫辛酸组14例,采用硫辛酸治疗;常规组15例,采用谷维素、维生素B2、维生素E。对比观察2组治疗前后疼痛改善程度,监测治疗过程药物不良反应发生情况。结果治疗前,硫辛酸组与常规组2组VAS评分差异无统计学意义(t=1.05,P>0.05)。治疗第1周,两组VAS评分横向比较,差异无统计学意义(t=0.09,P>0.05);治疗第2周,2组VAS评分差异有统计学意义(t=4.23,P<0.05);治疗第3周,2组VAS评分差异有统计学意义(t=3.97,P<0.05)。硫辛酸组治疗第1周(t=3.25,P<0.05)、2周(t=3.33,P<0.05)、第3周(t=4.27,P<0.05)VAS评分均低于治疗前,差异有统计学意义。常规组治疗第1周(t=2.93,P<0.05)、2周(t=3.71,P<0.05)、第3周(t=5.11,P<0.05)VAS评分均低于治疗前,差异有统计学意义。治疗过程中未监测到药物不良反应。结论硫辛酸可能具有缓解灼口综合征患者口腔黏膜疼痛的疗效。

Objective To explore the effects of lipoic acid in the treatment of burning mouth syndrome. Methods From May 2015 to May 2016, patients with burning mouth syndrome were selected and divided into experimental group（n=14） and control group（n=15）. Patients were treated with lipoic acid in the experiment group while oryzanol, vitamin B2 and vitamin were given in the control group. The pain degrees in two groups were compared before and after treatment, and the adverse drug reaction were monitored during the process. Results Before and after 1 week treatment, there was no statistical difference between VAS scores in two groups（P 0.05）. However, there were significant differences after 2 or 3 weeks（P 0.05）. Improvement of VAS score was found in both groups after treatment（P 0.05）. No adverse drug reaction was found during the treatment. Conclusion Lipoic acid can relieve the pain of patients with burning mouth syndrome.