急性脑梗死患者颈动脉硬化程度与血清Galectin-3表达水平的关系及阿托伐他汀钙的干预作用

The analysis of the relationship between carotid atherosclerosis and serum Galectin-3 level in patients with acute cerebral infarction and the intervention effect of atorvastatin calcium

目的探讨急性脑梗死患者颈动脉硬化程度与血清半乳凝集素-3(Galectin-3)表达水平的关系及阿托伐他汀钙的干预作用。方法选取本院2013年12月~2015年12月急性脑梗死患者92例,抽签随机分为观察组与对照组,每组各46例,给予对照组患者基础治疗,观察组患者在对照组治疗基础上加用阿托伐他汀钙治疗,分析急性脑梗死患者颈动脉硬化程度与血清Galectin-3表达的关系,比较观察组与对照组患者治疗前后血脂、血清炎性因子、血清Galectin-3水平及欧洲卒中量表(ESS)、日常生活量表(BI)评分。结果急性脑梗死患者颈动脉硬化程度越严重,血清Galectin-3水平越高(P<0.05);治疗后观察组患者各项血脂、血清炎性因子及Galectin-3水平均较对照组显著较低(P<0.05);观察组治疗后ESS及BI评分较对照组显著增高(P<0.05)。结论血清Galectin-3水平与急性脑梗死患者颈动脉硬化程度有关,给予患者阿托伐他汀钙治疗能显著改善血脂水平,降低炎性因子水平,且生活质量得到提高。

Objective To study the relationship between carotid atherosclerosis and serum Galectin-3 level in patients with acute cerebral infarction and the intervention effect of atorvastatin calcium. Methods From December 2013 to December 2015,92 patients with acute cerebral infarction in our hospital were randomly divided into the observation group and the control group,there were 46 cases in each group. The control group was given basic treatment,while the observation group was additionally treated with atorvastatin calcium. The relationship between the severity of carotid atherosclerosis and the expression of serum Galectin-3 in patients with acute cerebral infarction was explored. The blood lipids,serum inflammatory factors,serum Galectin-3 level,scores of European Stroke Scale（ ESS）and Barthel index（ BI） were compared between the two groups before and after treatment. Results The more serious carotid atherosclerosis was in patients with acute cerebral infarction,the higher the serum Galectin-3 level was（ P〈0. 05）. After treatment,the levels of blood lipids,the levels of serum inflammatory factors and serum Galectin-3 in the observation group were significantly lower than those in the control group（ all P〈0. 05）,while ESS and BI scores were significantly higher than those in the control group（ P〈0. 05）. Conclusion The level of serum Galectin-3 was positively correlated with the severity of carotid atherosclerosis in patients with acute cerebral infarction. The application of atorvastatin calcium could significantly improve the levels of blood lipids,reduce the levels of inflammatory factors,and improve the quality of life of patients.