依达拉奉联合银杏二帖内酯葡胺注射液治疗急性脑梗死的疗效观察

Efficacy observation of edaravone combined with ginkgo terpene lactones meglumine injection in the treatment of acute cerebral infarction

目的观察依达拉奉联合银杏二帖内酯葡胺注射液(GTLMI)治疗急性脑梗死的疗效及安全性。方法收集我院收治的70例急性脑梗死患者的临床资料,根据不同治疗方法分为常规治疗组(35例)和观察组(35例)。常规治疗组患者给予依达拉奉和常规基础治疗;观察组患者在此基础上联合GTLMI治疗。疗程均为14 d。观察对比两组患者治疗前、后神经功能缺损评分变化情况及临床疗效。结果治疗前,两组患者的神经功能缺损评分比较,差异不显著(P>0.05);治疗后,两组的神经功能缺损评分均显著降低(P<0.05),且观察组的神经功能缺损评分低于常规治疗组(P<0.05)。观察组总有效率为88.57%,高于常规治疗组的71.43%(P<0.05)。两组均无死亡病例。结论依达拉奉联合GTLMI治疗急性脑梗死安全有效,值得临床推广应用。

Objective To observe the efficacy and safely of combination between edaravone and ginkgo lerpene lactones meglumine injection （ GTLMI） on acute cerebral infarction. Methods Seventy cases of acute cerebral infarction palienls admitted in our hospilal were randomly divided into conventional group （35 cases） and observalion group （35 cases）. The conventional group received edaravone and conventional basic therapy, while lhe observalion group combined with GTLMI on lhe basis of lhe conventional group. Treatment lime was 14 days. The neurological deficit scores and e^icacy before and after treatment of lhe lwo groups were compared. Results Before treatment, lhe difference of neurological deficit scores between lhe lwo groups was nol statistically significant （ P 〉0.05）; after treatment, lhe scores of lhe lwo groups were both decreased （ P〈0.05）; and lhal of lhe observalion group was siginificanlly lower than lhe conventional group （ P〈0.05）. The lolal effective rale of lhe observalion group was 88.57%, which was higher than 71.43% of lhe conventional group （ P〈0.05）. No death occurred in either of lhe groups. Conclusion The combination of edaravone and GTLMI can play a protective effect on acute cerebral infarction, which is worth popularizing in clinical use.