肾动脉介入栓塞术联合自体DC-CIK细胞免疫治疗中晚期肾癌的疗效观察

Efficacy of renal artery embolization combined with autologous DC-CIK cells in the treatment of advanced renal cell carcinoma

目的观察中晚期肾癌患者经肾动脉介入栓塞术联合DC-CIK细胞免疫治疗的临床效果。方法将90例中晚期肾癌患者按照治疗方法分为两组。试验组(n=47)采用DC-CIK细胞免疫联合介入栓塞化疗,对照组(n=43)仅进行介入栓塞化疗。观察治疗前、后两组患者细胞亚群及细胞因子水平变化情况、临床疗效、生存质量、体质量改善情况及不良反应。结果试验组CD3^+、CD4^+、CD8^+、CD56^+及CD4^+/CD8^+改善情况、临床疗效、KPS评分及体质量改善情况均优于对照组(P<0.05);两组均未发生严重的不良反应。结论经肾动脉介入栓塞术合并DC-CIK细胞免疫治疗中晚期肾癌患者疗效显著,可显著改善患者的生存质量。

Objective To observe the clinical effect of renal artery embolization combined with autologous DC-CIK in the treatment of advanced renal cell carcinoma. Methods Ninety cases of palienls with advanced renal cell carcinoma were divided into two groups according to different treatment methods. The experimental group （ n=47） was treated with renal artery embolization chemotherapy combined with autologous DC-CIK, and lhe control group （ n=43） received embolization chemotherapy. The changes of cell subsets and cytokine levels before and after treatment, clinical efficacy and adverse reactions were observed. Results The levels of CD3＋, CD4＋, CD8＋, CD56＋ and CD4＋/CD8＋, clinical effect, KPS score and body mass in lhe experimental group were significantly superior lo those in lhe control group （ P〈0.05）, and without adverse reactions occurring in lhe lwo groups. Conclusion Renal artery embolization combined with DC-CIK cell immunotherapy in lhe treatment of advanced renal cell carcinoma has significant effect, which can significantly improve lhe quality of life.