血清CysC、Cr及LDH检测在多发性骨髓瘤早期肾损伤诊断中的应用研究

Application of serum CysC, Cr and LDH detection in the diagnosis of early renal injury of multiple myeloma

目的探究血清胱抑素C(CysC)、肌酐(Cr)及乳酸脱氢酶(LDH)检测在多发性骨髓瘤早期肾损伤诊断中的应用价值。方法选择我院收治的初步诊断为多发性骨髓瘤患者56例为观察组,选择同期在我院进行健康体检的56名健康者为对照组,比较两组的CysC、Cr、LDH水平并记录观察组各指标单项和联合检测值。结果与对照组相比,观察组CysC、Cr、LDH水平均明显上升(P<0.05);CysC、Cr、LDH单项检测,CysC+Cr+LDH联合检测阳性率比较,差异显著(χ~2=37.264,P<0.05),且CysC+Cr+LDH联合检测阳性率均高于单独检测,CysC、LDH单项基检测阳性率高于Cr单项检测(P<0.05)。结论 CysC、Cr、LDH联合检测多发性骨髓瘤的灵敏度明显高于单项检测,利于临床早期发现多发性骨髓瘤肾损伤。

Objective To invesligale the application value of serum cyslalin C （ CysC）, creatinine （ Cr） and laclale dehydrogenase （ LDH） deleclion in lhe diagnosis of early renal injury of mulliple myeloma. Methods Fifly-six cases of palienls wilh mulliple myeloma in our hospilal were selecled as lhe observalion group, and 56 cases of heallhy people in lhe same period were selecled as lhe conlrol group, lhe levels of CysC, Cr and LDH were delecled and lhe posilive rales of single deleclion and joinl deleclion were compared and recorded in lhe lwo groups. Results Compared wilh lhe conlrol group, lhe CysC, Cr, LDH levels of lhe observalion group were significanlly increased （P〈0.05）; lhere were significanl differences on lhe posilive rales of CysC, Cr, LDH single deleclion and CysC ＋ Cr ＋ LDH joinl deleclion （/字2=37.264, P〈0.05）, and lhe posilive rales of CysC ＋ Cr ＋ LDH joinl deleclion was higher lhan lhose of lhe CysC, Cr, LDH single deleclion, lhe posilive rales of CysC, LDH single deleclion were higher lhan lhal of Cr （ P 〈0.05）. Conclusion The sensilivily of joinl deleclion of CysC, Cr and LDH significanlly increases compared wilh lhal of lhe single deleclion, whichis beneficial lo lhe early deleclion of early renal injury of mulliple myeloma.