老年反流性食管炎应用奥美拉唑与雷贝拉唑治疗的临床效果比较

Clinical effects comparison of omeprazole and rabeprazole in elderly patients with reflux esophagitis

目的探讨老年反流性食管炎应用奥美拉唑与雷贝拉唑治疗的临床效果。方法选择我院2013年8月至2016年8月收治的老年反流性食管炎患者90例随机分为观察组和对照组,每组45例。对照组患者给予奥美拉唑进行治疗,观察组患者给予雷贝拉唑进行治疗。比较两组患者的临床效果。结果观察组患者的治疗总有效率为97.78%,明显高于对照组的75.56%(P<0.05)。观察组患者的黏膜损伤程度改善总有效率为97.78%,高于对照组的77.78%(P<0.05)。两组患者的不良反应总发生率及疾病复发率比较,差异有统计学意义(P<0.05)。结论与奥美拉唑比较,雷贝拉唑应用于老年反流性食管炎患者可以确保药效快速发挥,并且药物不良反应较少,可以有效避免患者出现反流性食管炎疾病复发,显著提高患者的生活质量。

Objective To investigate the clinical effects of omeprazole and rabeprazole in elderly patients with reflux esophagitis. Methods A total of 90 cases of elderly patients with reflux esophagitis admitted in our hospital from August2013 to August 2016 were selected and divided into control group and observation group, with 45 cases in each group.Patients in the control group were given omeprazole, while patients in the observation group were given rabeprazole. The clinical effects were compared between the two groups. Results After treatment, the treatment total effective rate of the observation group was 97.78%, which was higher than 75.56% of the control group(P<0.05). The mucosal injury improvemen total effective rate of the observation group was 97.78%, which was higher than 77.78% of the control group(P<0.05). The differences in the total incidence rate of adverse reactions and reoccrance in the two groups were significant(P <0.05).Conclusion Compared with omeprazol, using rabeprazole in elderly patients with reflux esophagitis can ensure rapid pesticide effect delivery and has less adverse drug reactions. It can effectively prevent the recurrence of reflux esophagitis, and significantly improve the quality of life of the patients.