阿奇霉素治疗小儿肺炎的临床效果分析

Clinical effect analysis of azithromycin in the treatment of infantile pneumonia

目的评价阿奇霉素不同用药方法治疗小儿肺炎的疗效与安全性。方法选取2014年2月至2016年4月收治的84例小儿肺炎支原体肺炎患儿,采用随机数字表法分为对照组和观察组,各42例。两组均给予基础治疗,对照组先给予红霉素而后常规应用阿奇霉素治疗,观察组给予阿奇霉素序贯治疗,观察两组的治疗效果。结果观察组退热时间、咳嗽消失时间、住院时间明显短于对照组(P<0.05);治疗后两组血清CRP水平明显低于治疗前,且观察组明显低于对照组(P<0.05);两组并发症、不良反应及难治性肺炎发生率无明显差异(P>0.05)。结论应用阿奇霉素序贯治疗小儿肺炎可明显提高治疗效果。

Objective To evaluate the efficacy and safety of different administration methods of azithromycin in the treatment of infantile pneumonia. Methods Eighty-four cases of children with mycoplasma pneumoniae pneumonia from February2014 to April 2016 in our hospital were selected and randomly divided into control group and observation group, with 42 cases in each group. All the patients received basic treatment, the control group was treated with erythromycin and then azithromycin, while the observation group was given azithromycin sequential therapy, the treatment effects were compared in the two groups. Results The antipyretic time, cough disappearance time and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05); after treatment, the serum CRP levels of the two groups were significantly lower than those before treatment, and those the observation group were significantly lower than the control group(P<0.05). The incidence rates of complications, adverse reactions and refractory pneumonia in the two groups were not statistically significant(P>0.05). Conclusion The application of azithromycin sequential treatment on infantile pneumonia can significantly improve the treatment effect.