山东省2012-2016年患者1,3-β-D葡聚糖检测结果分析

Analysis of 1,3-β-D glucan test results among patients in Shandong Province during 2012-2016

目的分析山东省立医院住院患者1,3-β-D葡聚糖检测(G试验)阳性率,了解山东地区患者的深部真菌感染情况。方法对2012年8月至2016年8月13 038例住院患者进行G试验检测,并对结果进行统计学分析。结果 G试验阳性率为13.79%(1 798/13 038);其中男性阳性率为13.52%(1 126/8 331),女性阳性率为14.28%(672/4 707)。0~<10岁阳性率为14.92%;10~<20岁、20~<30岁开始降低,分别为11.84%、11.07%;30~<40岁阳性率最高,为15.39%;此后,阳性率又逐渐降低,40~<50岁阳性率为14.26%,50~<60岁为13.66%,≥60岁为13.29%。秋季阳性率最高,为14.64%,其次分别为夏季13.81%、春季13.71%、冬季13.18%,但季节间阳性率差异无统计学意义(P>0.05)。消化科、神经科、风湿免疫科、呼吸科阳性率较高,阳性率分别为17.32%、17.28%、16.48%、13.05%;血液科阳性率为12.31%,重症科阳性率为9.63%;内分泌科阳性率最低,为7.64%。结论山东地区G试验阳性率具有年龄、科室差异,没有性别和季节差异。深部真菌感染者应早诊断,早治疗。

ObjectiveTo analyze the positive rate of 1,3 β D glucan test（G test）among the inpatients of our hospital in order to know the infection status of invasive fungal infection（IFI）in Shandong area.MethodsThe G test was conducted in 13 038 inpatients with suspected IFI from August 2012 to August 2016 and the results were statistically analyzed.ResultsThe positive rate of G test was 13.79%（1 798/13 038）,which was 13.52%（1 126/8 331）in male and 14.28%（672/4 707）in female.The positive rate of G test was increased to 14.92% in the 0-〈10 years old group,and began to decrease from the 10-〈20 years old group and 20-〈30 years old group,which were 11.84% and 11.07% respectively;the positive rate in the 30-〈40 years old group reached highest（15.39%）and then the positive rate was decreased gradually,which was 14.26% in the 40-〈50 years old group,13.66% in the 50-〈60 years old group and 13.29% in the ≥60 years old group.The positive rate of G test was highest in autumn（14.64%）,followed by the summer（13.81%）,spring（13.71%）and winter（13.18%）,but the positive rate had no difference between the seasons.The positive rate was higher in the departments of gastroenterology,neurology,immunology and respiration,which were 17.32%,17.28%,16.48% and 13.05%,respectively;which was 12.31% in the hematology department,9.63% in ICU,while which was lowest in the endocrinology department.ConclusionThe positive rates of G test in Shandong area show the age differences and department differences,without sex and seasonal difference.The patients with IFI should be diagnosed early and treated early.