妊娠高血压孕妇妊娠中期的血脂及血脂蛋白研究

Study on blood lipid and lipoprotein during mid trimester of pregnancy in women with pregnancy induced hypertension

目的研究妊娠高血压孕妇妊娠中期的血脂及血脂蛋白的特点。方法回顾性分析2009年1月至2017年1月江苏省张家港市乐余人民医院分娩孕妇4 762例,其中患妊娠高血压疾病者286例(疾病组),血压正常4 476例(对照组)。观察2组孕妇18~24周的体质量指数(BMI)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、载脂蛋白(ApoA1、ApoB、ApoE)和脂蛋白[Lp(a)]。结果疾病组孕妇的BMI高于对照组,差异有统计学意义(P<0.05)。疾病组孕妇TG、LDL-C、TC均高于对照组,HDL-C低于对照组,差异有统计学意义(P<0.05)。2组孕妇ApoA1、ApoB、ApoE、Lp(a)水平比较差异无统计学意义(P>0.05)。妊娠高血压疾病的严重程度与TG、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关。结论妊娠高血压孕妇妊娠中期的血脂水平和BMI明显高于正常孕妇,Lp(a)水平与正常孕妇差异无统计学意义,可通过检测孕妇孕中期血脂水平,早期预测孕妇妊娠高血压疾病的发生和疾病严重程度。

ObjectiveTo investigate the characteristics of blood lipid and lipoprotein during the mid trimester of pregnancy in pregnant women with pregnancy induced hypertension.MethodsThe retrospective analysis was performed on 4 762 pregnant women in this hospital from January 2009 to January 2017,including 286 cases of hypertensive disorders in pregnancy（disease group）and 4 476 cases of normal blood pressure（control group）.the body mass index（BMI）,triglyceride（TG）,low density lipoprotein cholesterol（LDL C）,high density lipoprotein cholesterol（HDL C）,total cholesterol（TC）,apolipoprotein（ApoA1,ApoB,ApoE）and lipoprotein[Lp（a）] during 18-24 gestational weeks were observed in the two groups.ResultsBMI in the disease group was higher than that in the control group,the difference was statistically significant（P〈0.05）.TG,LDL C and TC in the disease group were higher than those in the control group,while HDL C was lower than that in the control group,the difference was statistically significant（P〈0.05）;there was no statistically significant difference in ApoA1,ApoB,ApoE and Lp（a）between the two groups（P〉0.05）;the severity of pregnancy induced hypertension was positively correlated with the levels of TG,LDL C and TC,and negatively correlated with HDL C level.ConclusionThe blood lipid level and BMI during middle stage of pregnancy in the pregnant women with gestational hypertension are significantly higher than those in the normal pregnant women,and the Lp（a）level has no statistically significant difference compared with normal pregnant women.Detecting the blood lipid level during the middle stage of pregnancy can early predict the occurrence and severity of pregnancy induced hypertension. lipid level can be used to predict the incidence and severity of pregnancy induced hypertension in pregnant women.