外周血TLR2和TLR9在小儿复发性单纯疱疹中的作用

The Role of Peripheral Blood TLR2 and TLR9 in Children with Recurrent Herpes Simplex

目的:研究外周血Toll受体2(TLR2)和Toll受体9(TLR9)在小儿复发性单纯疱疹(RHS)中的作用。方法:选择从2014年1月至2016年12月在我院就诊的RHS患儿46例纳入本次研究,将其记为观察组。另选同期在我院进行健康体检的儿童45例作为对照组。对比两组外周血TLR2及TLR9水平,白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及C反应蛋白(CRP)水平,采用Spearman相关性分析患儿外周血TLR2及TLR9水平与其炎症指标的相关性。结果:观察组外周血TLR2、TLR9和TLR2及TLR9双表达的水平均明显高于对照组(P<0.05)。观察组的IL-2水平较对照组降低(P<0.05),IL-4及CRP水平较对照组升高(P<0.05)。Spearman相关性分析显示,患儿外周血TLR2及TLR9水平与其IL-2呈负相关(P<0.05),与IL-4和CRP呈正相关(P<0.05)。结论:TLR2和TLR9在RHS患儿外周血中均具有较高表达,且与机体炎症因子IL-2、IL-4及CRP间具有紧密联系,值得临床重视。

Objective： To investigate the role of Toll-like receptor 2 （TLR2） and Toll-like receptor 9 （TLR9） in peripheral blood in children with recurrent herpes simplex （RHS）. Methods： 46 children with RHS who were admitted to our hospital from January 2014 to December 2016 were selected as the observation group. Over the same period, 45 healthy children were selected as a control group in our hospital. The levels of TLR2 and TLR9, the levels of interleukin-2（IL-2）, interleukin-4（IL-4） and C reactive protein （CRP） in peripheral blood of two groups were compared, and analyzed the correlation between TLR2, TLR9 levels in peripheral blood and inflammatory markers in children with RHS. Results： The levels of TLR2, TLR9, TLR2 and TLR9 in the peripheral blood of the observation group were significantly higher than those in the control group （P〈0.05）. The level of IL-2 in the observation group was lower than that in the control group, the levels of IL-4 and CRP were higher than those in the control group （P〈0.05）. Spearman found that the levels of TLR2 and TLR9 in peripheral blood were negatively correlated with IL-2, and positively correlated with IL-4 and CRP. Conclusion： TLR2 and TLR9 have high expression in peripheral blood of children with RHS, and they have close relationship with inflammatory factors IL-2, IL-4 and CRP, which is worthy of clinical attention.