革兰氏阴性细菌LuxR/Ⅰ型群体感应抑制剂研究进展

Research Advances in the LuxR/I Type Quorum Sensing Inhibitors of Gram-Negative Bacteria

细菌群体感应(Quorum sensing,QS)被视为对抗细菌感染与解决细菌耐药性问题的新靶点。以AHLs为信号分子的LuxR/Ⅰ型群体感应系统广泛存在于革兰氏阴性菌包括多种临床致病菌中,因此寻找LuxR/Ⅰ型群体感应抑制剂(Quorum sensing inhibitors,QSIs)是研发抗革兰氏阴性致病菌药物的重要途径。迄今为止,已知的LuxR/Ⅰ型小分子QSIs来源包括化学合成、天然产物与已知药物库的化合物,大分子则包括群体感应淬灭酶与群体感应淬灭抗体。本文总结了近年来LuxR/Ⅰ型QSIs研究进展,为新型抗菌药物研发提供理论依据。

Research of quorum sensing （QS） is supposed to be a new way to solve bacterial infection and antibiotic resistance problem. The LuxR/I type quorum sensing system with AHLs as signaling molecules are widely existed in the Gram- negative bacteria including many kinds of clinical pathogens. So it is an important approach for developing Gram- negative pathogenic bacteria drugs to exploit the LuxR/I type quorum sensing inhibitors （QSIs）. Of the LuxR/I type QSIs that have been discovered so far, the small molecular QSIs include synthetic compounds, natural products, and the compounds screened from known drugs, while the macro-molecule QSIs include the quorum quenching enzymes and the quorum quenching antibodies. This article reviewed the advance of LuxPUI type QSIs discovered in recent years to provide theoretical basis for developing new antibacterial drugs.