低氧对学习记忆相关蛋白的影响研究进展

Research Progress for the Effect of Learning and Memory related Protein in Hypoxia Environment

低氧暴露能够引起机体不同程度的损伤,尤其是对中枢神经系统的影响,它可以通过影响一些学习记忆相关蛋白,从而对大脑的学习记忆能力产生影响。这篇综述以介绍学习记忆相关蛋白为重点,分别阐述了低氧对FABP5、ERRγ、FOXP2、Iduna及tau蛋白等的影响和作用机制,为临床防治由于高原环境引起的大脑学习记忆损伤提供理论依据。

Hypoxia exposure can result in different damage to the body. Especially, it have obvious effects on the nerve system. It can cause and aggravate cerebra learning and memory impairment through influencing some learning and memory related protin. This review focus on the introduction of learning memory related proteins, such as fatty Acid-binding Protein 5, estrogen-related receptor γ, forkhead box p2, Iduna protein and tau protein and so on. Whats＇ more, it also respectively elaborate that the influence of hypobaric hypoxia environment to these proteins and to provide theory evidence for the clinical prevention and treatment of cerebrum learning and memory impairment caused for the high altitude environment.