高血压患者脂蛋白a与颈动脉内-中膜厚度的关系研究

Association Between Lipoprotein(a) and Intima-media Thickness of Carotid Artery in Patients With Hypertension

目的探讨原发性高血压患者血清脂蛋白a与颈动脉内-中膜厚度的关系。方法选取我科2014年7月—2016年11月158例原发性高血压患者,以同期门诊体检健康者54例为对照组。所有对象均检测脂蛋白a、行颈动脉彩超检查。158例高血压患者经彩超证实为内-中膜增厚作为研究组,54例体检健康者经证实为内中膜正常作为对照组。比较两组间的血清脂蛋白a水平,同时分析脂蛋白a水平与颈动脉内-中膜厚度的相关性。结果颈动脉内-中膜增厚组脂蛋白a水平明显高于对照组,而且脂蛋白a水平与颈动脉内-中膜厚度呈正相关。结论脂蛋白a水平升高是增加原发性高血压颈动脉内-中膜增厚的危险因素,能预测颈动脉粥样硬化的发生。

Objective To investigate the association between lipoprotein（a）[Lp（a）] and intima-media thickness（IMT） of carotid artery in patientswith hypertension. Methods 158 patients with essential hypertension inour hospital from July 2014 to November 2016 were selected, and 54healthy subjects were enrolled as control group. Serum Lp（a） levels andcarotid artery ultrasonography were measured in all subjects. Accordingto the results of carotid ultrasound, 158 essential hyptensive patientswere confrmed as intima-media thickened group and 54 healthy personsas normal IMT group. Serum Lp（a） levels were compared among the 2groups. The correlation between Lp（a） levels and IMT were investigatedResults The concentrations of serum Lp（a） were significantly higherin intima media thickened group than normal IMT group. There was apositive correlation between Lp（a） levels and IMT. Conclusion The higherserum Lp（a） was the risk factor for carotid artery atherosclerosis and morelikely to predict it in hypertension.