某院甲磺酸阿帕替尼临床使用情况分析与对策

Clinical Use of Apatinib of Inpatients in a Hospital and Countermeasures

目的对某院抗肿瘤靶向药物甲磺酸阿帕替尼临床应用情况进行回顾性调查分析并评价。方法调取某院2015年1月—2016年12月使用阿帕替尼的病例,评价其用药合理性及安全性。结果 2015年1月—2016年12月使用阿帕替尼的患者63例,符合药品说明书适应证有23例(占36.5%),不良反应主要为高血压、蛋白尿、皮肤毒性反应及骨髓抑制等。结论阿帕替尼在临床应用中存在超说明书适应证用药、用法用量不适宜,临床上应重视该药的合理使用,临床药师应以此为工作切入点,提高药物治疗的安全性和有效性,促进临床合理用药。

Objective To retrospectively analyze and evaluate targeted antitumor drug mesylate apatinib clinical application in a hospital. Methods The medicalrecords including apatinib were collected from January 2015 to December 2016. Then, the rationality and safety of drug use were evaluated. Resulis The 63 patients used apatinib during this time,while 23 patients （36.5%） conformed to the approved indications.The main adverse reactions were hypertension, proteinuria, skin toxicity and bone marrow suppression. Conclusion Irrational use of apatinib such as offabel use, inadequate usage and dosage exists in clinic, and clinical pharmacists can improve the safety and effectiveness of therapeutic drugs by taking this as the break-through point.