纳豆激酶,一种潜在的用于预防与治疗心血管疾病的功能食品添加剂

Nattokinase, a potential functional food additives for cardiovascular disease prevention and treatment

纳豆激酶是一种具有高效纤维蛋白溶解活性的丝氨酸蛋白酶,由枯草属菌株、假单胞菌属菌株和海洋生物合成。与常规的纤维蛋白溶解酶相比,纳豆激酶具有高效、无毒、半衰期长、可以口服、成本低廉等优点,在功能性食品添加剂和心血管疾病预防与治疗等方面极具应用潜力。对纳豆激酶及其生产菌株选育、发酵条件优化、重组表达、分子改造、分离纯化、功能研究和安全评估等方面进行了简单介绍,并归纳总结了纳豆激酶现有问题,同时就其生产和应用前景进行了展望。

Xylan is the main component of hemicellulose and also the second most abundant renewable resource in nature.Due to the stable and complex structure of xylan,it is diffi cult to degrade itself under natural condition.So a variety ofenzymes are needed to better hydrolysis xylan or substrate which contained xylan.Xylanase system is mainly producedwith microorganisms,and characteristics are different between different sources of xylanase.This paper described thecomposition and hydrolysis mechanism,the classifi cation and enzyme characteristic,and the application of xylanase infood fi eld.