不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响

Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

目的探讨采用不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响.方法选取陕西延安大学附属医院2015年5月到2016年5月收治的62例慢性阻塞性肺疾病急性加重期患者,将患者随机分为A组和B组,每组各31例患者.为A组患者采用盐酸氨溴索注射液治疗,每次330 mg,B组每日盐酸氨溴索注射液90 mg治疗,对比2组患者第1天、第4天以及第7天痰液中IL-6、IL-8以及TNF-α指标.结果 2组患者入院治疗后第1天,痰液中IL-6、IL-8以及TNF-α指标之间的差异相对较小,不存在统计学意义(P>0.05).患者入院治疗第4天、第7天,A组患者各项指标下降速度均显著优于B组患者,差异对比均存在统计学意义(P<0.05);2组不良反应发生率差异没有统计学意义(P>0.05).结论短时间内应用大剂量盐酸氨溴索注射液,能够快速降低老年慢性阻塞性肺疾病急性加重期患者的临床症状,降低患者痰液中的IL-6、IL-8以及TNF-α指标,具有较好的抗炎价值,建议广泛应用.

Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on theinflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients withacute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acuteexacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A andB,31 cases in each group. The Group A was given Ambroxol Hydrochloride Injection treatment,330 mg per time, andGroup B was given 90 mg Ambroxol Hydrochloride Injection treatment. The IL-6,IL-8,and TNF-α Index on the1st day,4th day and 7th day after the treatment in these two groups were compared. Results On the 1st day, thesputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups（ 〉0.05） . On the first 4th day and 7th day, the decrease of the indicators of patients in A group was significantlybetter than group B patients,and the difference was statistically significant（ 〈0.05） .There was no significantdifference in the incidence of adverse reactions between the two groups（ 〉 0.05） .Conclusion Theapplication of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient＇s sputumIL-6,IL-8 and TNF-αindex,has better anti-inflammatory effect and deserves wide application.