猪链球菌2型感染的A549细胞表达谱研究

Study on Microarray Gene Expression Profile of A549 Cells Infected with Streptococcus suis Type 2

采用人全基因组芯片的方法研究猪链球菌2型感染的A549细胞中各基因的表达变化。结果表明,有130个基因的表达具有显著性差异,其中61个基因表达为上调,69个基因表达下调。通过分析,其中77个差异表达基因可分为32个生物学功能类别,包括了信号转导、细胞凋亡、Toll样受体信号通路、细胞分化等生物学过程。

The microarray was used to study the different expressions of genes in A549 cells after the Streptococcus suis type 2 infection.In the results, 130 genes were expressed differentially,including 61 up-regulated genes and 69 down-regulated genes.By Biological process classification,77 major DE genes involved in 32 biological function types, including signal transduction, apoptosis, Toll-like receptor signaling pathway and differentiation.