表面活性剂对辅料接触角的影响

Influences of Surfactants on Contact Angle of Pharmaceutical Excipients

目的:考察不同浓度表面活性剂对辅料接触角的影响,从而进一步考察不同表面活性剂对辅料润湿性的影响及表面活性剂与辅料不同配比对片剂润湿性的影响。方法:选取不同种类的辅料进行压片,配制不同浓度的表面活性剂溶液,利用接触角测定仪,测定溶液在片剂表面的接触角。结果:在临界胶束浓度下的表面活性剂与片剂的接触角最小,润湿性最好,对于大多数相同浓度下的表面活性剂,亲水性辅料片剂接触角的改变小于疏水性材料。结论:表面活性剂的加入,可以显著降低辅料片剂接触角,但是达到某一比例之后接触角变稳定。该研究结果对片剂处方设计具有一定参考价值。

Objective： To investigate the effect of surfactants on contact angle of pharmaceutical excipients and further study the effect of surfactants at different concentrations on the wettability of excipients and the effect of of surfactants and excipients at different proportions on the wettability of tablets. Methods： Different kinds of excipients were selected for tabletting, and surfactant solutions at different concentrations were prepared. The contact angle of the solutions on the surface of the tablets was measured by a contact angle tester. Results： The contact angle between the surfactants below the critical micelle concentrations and the tablets was the smallest and the wettability was the best. The change of the contact angle on the tablets with hydrophilic materials was less than that with hydrophobic ones for most of the surfactants at the same concentration. Conclusion： After the addition of surfactants, the contact angle of excipient tablets significantly decreases, however, the contact angle will be stable after the amount of surfactants reaches a certain ratio, which shows significant reference value for tablet formula design.