国产盐酸洛美沙星滴眼剂抑菌效力考察

Antimicrobial Effectiveness of Domestic Lomefloxacin Hydrochloride Eye Drops

目的:考察市售13家企业盐酸洛美沙星滴眼剂的抑菌效力。方法:依据中国药典2015年版四部《抑菌效力检查法》测定盐酸洛美沙星滴眼液的抑菌效力。结果:被考察的13家企业样品中,有5家企业样品达到标准"A",有3家企业样品达到标准"B",5家企业样品不符合规定。结论:目前国产盐酸洛美沙星滴眼液抑菌剂的使用还存在一定问题,建议生产企业根据2015年版药典并结合自身处方本着最低有效的原则优化抑菌剂使用的种类和浓度。

Objective： To evaluate the antimicrobial effectiveness of lomefloxacin hydrochloride eye drops from 13 domestic manufacturers. Methods： The antimicrobial effectiveness of lomcfloxacin hydrochloride eye drops was tested based on the antimicrobial effectiveness testing in Chinese Pharmacopoeia （2015 edition, volume 4）. Results： The samples from 5 manufacturers could reach level A, those from 3 manufacturers were at level B, and those from 5 manufacturers did not comply with the specification. Conclusion： Some problems exist in the usage of antimierobial agents in lomefloxaein hydrochloride eye drops from some Chinese manufacturers, and these manufacturers should optimize the type and concentration of antimicrobial agents according to the requirements of Chinese Pharmacopoeia combined with the corresponding prescriptions under the principle of minimum concentration while best effect.