痰热清注射液佐治严重脓毒症的疗效及其对高密度脂蛋白胆固醇的影响

Efficacy of Tanreqing injection in the treatment of serve sepsis and its effect on serum high-density lipoprotein cholesterol

目的探讨痰热清注射液对严重脓毒症患者高密度脂蛋白胆固醇(HDL-C)水平的影响。方法选取2015年1月至2016年12月收住重庆市荣昌区人民医院重症医学科的72例严重脓毒症合并低HDL-C患者为研究对象,按随机数表法分为对照组和观察组各36例,对照组予常规综合治疗,观察组在对照组基础上加用痰热清注射液,疗程均为7 d。比较两组患者治疗前后的血清HDL-C、载脂蛋白A1(apo A1)水平、APACHEⅡ评分的变化及住ICU时间和总住院时间。结果两组患者入科后的APACHEⅡ评分、血浆HDL-C、apo A1水平比较差异均无统计学意义(P>0.05);两组患者住ICU时间比较差异无统计学意义(P>0.05);总住院时间观察组为(14.33±5.21)d,明显低于对照组的(18.36±4.43)d,差异有统计学意义(P<0.05);治疗后观察组患者的APACHEⅡ评分为(10.11±2.13)分,明显低于对照组的(14.33±2.87)分,差异有统计学意义(P<0.05);治疗后观察组患者的HDL-C、apo A1水平分别为(0.81±0.33)mmol/L、(1.34±0.55)g/L,明显高于对照组的(0.59±0.28)mmol/L、(0.91±0.320)g/L,差异均有统计学意义(P<0.05)。结论痰热清注射液佐治脓毒症可提高严重脓毒症患者体内HDL-C水平,缩短病程,提高临床疗效。

Objective To investigate the effects of Tanreqing injection on serve sepsis patients with high-densi-ty lipoprotein cholesterol （HDL-C）. Methods A total of 72 serve sepsis patients with low HDL-C, who admitted to Department of Critical Care Medicine of Rongchang District People＆#39;s Hospital from Jan 2015 to Dec 2016, were select-ed and randomly divided into the two groups according to the random number table method, with 36 cases in each group. The control group was given conventional treatment, and the Tanreqing injection group was treated with Tanreq-ing injection and conventional treatment. The course of treatment was 7 d. The clinical curative effect, Acute Physiolo-gy and Chronic Health Enquiry （APACHEⅡ） score, serum HDL-C and apoA1 were compared between two groups. Results At admission, there were no significant differences in patients＆#39; APACHEⅡscore, plasma values of HDL-C and apoA1 between the two groups （P〉0.05）. There were no significant differences in the ICU time between the two groups （P〉0.05）. Hospitalization time in the Tanreqing group was （14.33 ± 5.21） d, which was significantly shorter than （18.36±4.43） d of the control group （P〈0.05）. After treatment, the APACHEⅡscore was （10.11±2.13） in the Tanreqing injection group, which was significantly lower than （14.33 ± 2.87） of the control group （P〈0.05）; the serum HDL-C, apoA1 in both groups were significantly reduced, and those in the Tanreqing group were （0.81±0.33） mmol/L and （1.34± 0.55） g/L, respectively, which were significantly better than （0.59 ± 0.28） mmol/L and （0.91 ± 0.32） g/L in the control group （P〈0.05）. Conclusion The application of Tanreqing injection in serve sepsis patients is able to improve the HDL-C levels, shorten the treatment course, and increase the clinical efficacy.