基于细胞通路的针灸治疗类风湿关节炎镇痛、抗炎机制研究

Research of Analgesia and Anti-inflammatory Mechanism of Rheumatoid Arthritis Treated with Acupuncture and Moxibustion based on Cell Pathway

信号通路的异常激活与类风湿关节炎(RA)的发生、发展密切相关。针刺可通过阻断信号传导通路的活化,抑制促炎因子的增加,促进抑炎因子分泌,从而发挥抗炎、镇痛的作用。然而目前的研究也存在一些问题,如相关细胞通路间的系统联系不够;研究水平不高;研究缺乏中医整体观等。因此,通过针灸治疗类风湿关节炎机制的相关文献进行总结,从针灸与细胞传导通路的关系探讨针灸治疗RA的镇痛、抗炎机制,有望在针灸治疗RA机制方面取得新的进展,发现新的研究方向。

The abnormal activation of signal pathway is closely related to the occurrence and development of rheumatoid arthritis （RA）. Acupuncture can block the activation of the signaling pathway, inhibit the increase in proinflammatory factors, and promote the secretion of anti-inflammatory factors, thus play a role in anti-inflammatory and analgesic. However, the current research also has some problems, such as the relevant cell pathway between the system is not enough and research level is not high, the lack study of traditional Chinese medicine and so on. Therefore, this article summarizes the related literature of acupuncture and moxibustion treatment of rheumatoid arthritis, and discusses the analgesic and anti-inflammatory mechanism of acupuncture and moxibustion treatment of acupuncture and moxibustion. It is expected that new progress will be made in acupuncture treatment of RA mechanism. New research direction.