邓铁涛浴足方对肝阳上亢型高血压病的外治干预作用

Intervention Effect of DENG Tie-Tao's Foot-bath Recipe on Essential Hypertension with Hyperactivity of Liver Yang syndrome

【目的】观察邓铁涛浴足方对肝阳上亢型高血压病的外治干预作用。【方法】选取肝阳上亢型高血压病患者80例,随机分为治疗组和对照组,每组各40例。2组均给予相同的西药降压基础治疗,治疗组同时加入邓铁涛浴足方(组方为:牛膝、川芎、夏枯草、吴茱萸、钩藤等)浴足干预,对照组则同时加入温水浴足,以7 d为1个疗程。观察2组患者治疗前后中医证候积分、阿森斯失眠量表积分的变化情况,并用动态血压计检测2组患者的血压变异性(BPV),应用酶联免疫吸附(ELISA)法测定2组患者血浆去甲肾上腺素(NE)、肾上腺素(E)水平变化。【结果】(1)中医证候疗效:治疗组总有效率为87.5%,对照组为75.0%,治疗组的中医证候疗效优于对照组(P<0.05)。(2)血压疗效:治疗组总有效率为85.0%,对照组为72.5%,治疗组的血压疗效优于对照组(P<0.05)。(3)治疗后,2组阿森斯失眠量表总分值均明显降低(P<0.01),且治疗组的降低作用明显优于对照组,差异有统计学意义(P<0.01)。(4)治疗后,2组24h BPV、日间BPV和夜间BPV均有一定程度降低(P<0.05),且治疗组在降低24h BPV和夜间BPV方面优于对照组(P<0.05)。(5)治疗后,2组血浆NE及E水平均明显降低(P<0.05),且治疗组的降低作用均明显优于对照组(P<0.05)。【结论】邓铁涛浴足方可以显著改善肝阳上亢型高血压病患者的临床症状及睡眠质量,减少24 h血压变异性以协同实现平稳降压;而调节血浆NE及E水平可能是其作用机制之一。

Objective To observe the therapeutic effect of DENG Tie-tao＇s Foot-bath Recipe（mainly composed of Radix Achyranthis Bidentatae,Rhizoma Chuanxiong,Spica Prunellae,Fructus Evodiae,Ramulus Uncariae Cum Uncis,etc.）for the treatment of essential hypertension with hyperactivity of liver Yang syndrome. Methods Eighty essential hypertension patients with hyperactivity of liver Yang syndrome were randomly divided into treatment group and control group,40 cases in each group. Both groups were given basic antihypertensive western medicine treatment, and additionally the treatment group was given external application of DENG Tie-Tao＇s Foot-bath Recipe and the control group was given foot-bath with warm water. Seven days constituted one treatment course. Before and after treatment, the scores of traditional Chinese medicine（TCM）symptoms and Athens Insomnia Scale were observed, blood pressure variability（BPV） was detected with ambulatory blood pressure monitoring instrument, and plasma norepinephrine（NE） and epinephrine（E） levels were examined by enzyme-linked immunosorbent assay（ELISA）. Results（1）The total effective rate for improving TCM symptom scores of the treatment group was 87.5%, and that of the control group was 75.0%, the difference being significant（P〈0.05）.（2）The total effective rate for lowering blood pressure of the treatment group was85.0%, and that of the control group was 72.5%, the difference being significant（P〈0.05）.（3）After treatment,scores of Athens Insomnia Scale in the two groups were obviously decreased（P〈0.01 compared with those before treatment）,and the decrease in the treatment group was superior to that in the control group（P〈0.01）.（4）After treatment,24 h BPV,daytime BPV and night BPV in the two groups were decreased to certain degrees（P〈0.05 compared with those before treatment）,and the decrease of 24 h BPV and night BPV in the treatment group was superior to that in the control group（P〈0.05）.（5）After treatment,plasma NE and E levels in the two groups were decreased to certain degree（P〈0. 05 compared with those before treatment）, and the decrease in the treatment group was superior to that in the control group（P〈0.05）. Conclusion DENG Tie-Tao＇s Foot-bath Recipe exerts synergistic action on lowering blood pressure steadily by relieving TCM symptoms, improving the quality of sleep, decreasing 24 h BPV of essential hypertension with hyperactivity of liver yang syndrome. And the regulation of plasma NE and E levels may be one of its therapeutic mechanisms.