肾性贫血维持性血液透析患者EPO剂量调整与血红蛋白变异度的关系研究

The research about the relationship between Erythropoietin level change of patients with renal anemic hemodialysis and hemoglobin variability

目的探讨维持性血液透析贫血达标患者促红细胞生成素(Erythropoietin,EPO)剂量微调对于血红蛋白变异的影响。方法收集维持性血液透析肾性贫血纠正达标患者,每月检测1次血红蛋白,根据血红蛋白波动值给予EPO剂量微调(EPO基础值增加或减少15%EPO剂量)连续检测12个月,观察对血红蛋白变异的影响。结果 6个月内30%患者的血红蛋白维持在靶目标范围内,17%患者血红蛋白波动≤10g/L,血液透析的充分性影响血红蛋白的变异度及达标率。结论 EPO剂量微调可以减少血红蛋白变异度,维持血红蛋白的稳定性。

Objective To discuss the influence of Erythropoietin（EPO）level change for hemoglobin mutation in maintenance hemodialysis anemia patience.Methods The information of renal anemia patience for maintenance hemodialysis was collected to observe the influence of hemoglobin mutation continuously for 12 months by checking hemoglobin level once per month and changing EPO amount based on hemoglobin fluctuation（＋/-15% EPO amount）.Results The sufficiency of maintenance hemodialysis influenced hemoglobin mutation and control rate.It was based on the result that the hemoglobin level of 30% patience maintained within control range during the 6 months period while 17% of them had hemodialysis fluctuation≤10 g/L.Conclusion EPO level change can reduce hemoglobin mutations and maintain the stability of hemoglobin.