男性血清锌α2糖蛋白与血脂、生殖激素的关联性研究

Correlation of serum zinc alpha 2 glycoprotein with blood lipid and reproductive hormone levels in men

目的:了解男性血清锌α2糖蛋白(ZAG)的水平变化及其与生殖激素的关系。方法:选取25~65岁体检男性297例,按血脂水平分为对照组145例和高脂组152例;按年龄分为25~35岁、36~45岁、46~55岁、56~65岁4个年龄组;依据血清ZAG水平的三分位数分为3组(Q1,Q2,Q3)。检测血脂、血糖、ZAG和生殖激素等,比较ZAG与代谢及生殖激素的关系。结果:(1)随着年龄的增长,对照组和病例组男性血清ZAG逐渐下降,在36~45岁和56~65岁明显下降,有统计学差异(P<0.05)。同年龄组中比较,25~35岁和36~45岁中,高脂组的ZAG水平明显低于对照组,有统计学差异(P<0.05)。(2)FSH在ZAG低、中、高水平组表达分别为(7.69±4.07)mIU/ml、(5.65±2.26)mIU/ml和(4.85±1.97)mIU/ml,3组之间比较差异有显著性(P<0.05);T在ZAG低、中、高水平组表达分别(2.93±1.08)ng/ml、(3.51±1.22)ng/ml和(3.89±1.37)ng/ml,3组之间比较差异有显著性(P<0.05)。(3)男性血清ZAG与年龄、WC、BMI、FBG、TG呈负相关(r=-0.58,-0.21,-0.22,-0.16,-0.27,P均<0.05);与TT呈正相关(r=0.36,P<0.05);年龄、BMI和TG是ZAG的独立影响因素。结论:男性血清锌α2糖蛋白随增龄而下降,与脂质代谢和腹型肥胖有关,并且其水平的变化和男性生殖激素有关。

Objective： To study the changes of the serum zinc alpha 2 glycoprotein （ZAG） level in men and its relationship with blood lipid male reproductive hormones. Methods： We enrolled 297 men aged 25 - 65 years in this study, 152 with hyper- lipemia （HL） and the other 145 with normal blood lipid （normal control）. We divided them into four age groups （25 -35 yr, 36 -45 yr, 46- 55 yr, and 56 -65 yr） and three tertile groups （Q1, Q2, and Q3 ） according to the tertiles of the serum ZAG level, and examined their blood lipid, blood glucose, serum ZAG, and reproductive hormones. Results： The serum ZAG level was decreased gradually with the increase of age in both the HL patients and normal controls, significantly in the 36 - 45 and 56 - 65 yr age groups （ P 〈 0.05 ）, and markedly lower in the HL than in the control men in the 25 - 35 and 36 - 45 yr groups （ P 〈 0.05 ）. The levels of follicle-stimulating hormone （FSH） and total testosterone （TT） changed significantly with the ZAG level. The level of serum ZAG was correlated negatively with age （r = - 0.58, P 〈 0.05）, waist circumference （r -- - 0.21, P 〈 0.05） , body mass index （BMI） （r = -0.22, P 〈0.05）, fasting blood glucose （r = -0.16, P 〈0.05） , and triglyceride （TG） （r = -0.27, P 〈0.05） but positively with TT （r = 0.36, P 〈 0.05）. Age, BMI and TG were independent factors influencing the serum ZAG level. Conclu- sion ： The serum ZAG level is decreased with the increase of age and associated with lipid metabolism, abdominal obesity, and repro-ductive hormone levels in males.