抗生素治疗解脲支原体感染时阴道补充乳杆菌的效果评价

Effect of lactobacillus supplementation via vagina during antibiotic treatment of Uu infection

目的评估在用抗生素治疗解脲支原体感染的过程中,使用定君生胶囊补充阴道乳杆菌在促进感染治愈,预防并发症外阴阴道假丝酵母菌病的效果。方法 2014年7月至2016年7月开展临床试验研究,研究组中100名患者口服盐酸多西环素同时阴道补充乳杆菌活菌胶囊定君生每天1粒共10d,对照组127名患者仅口服盐酸多西环素。计算治疗期间以及复查前停药阶段外阴阴道假丝酵母菌病发生率,停药满14d后解脲支原体治愈率以及被治愈患者停药满3个月内解脲支原体复发率。结果研究组停药14d后解脲支原体的治愈率高于对照组(88.0%vs 77.2%,P=0.035),同时,治疗期间和复查前停药阶段外阴阴道假丝酵母菌病的发生率较低(8.0%vs 18.9%,P=0.019),但两组停药满3个月内解脲支原体感染复发率差异无显著性(8.9%vs 16.1%,P>0.05)。结论抗生素治疗解脲支原体感染同时阴道补充乳杆菌有利于提高其治愈率,降低治疗和停药期间外阴阴道假丝酵母菌病发生率。

Objective To evaluate the effect of lactobacillus supplementation via vagina during antibiotic treatment of Ureaplasma urealyticum（Uu）infection in terms of promoting cure rate and preventing vulvovaginal candidiasis（VVC）.Methods The clinical trial was conducted from Jul 2014 to Jul 2016.The 110 subjects in the observation group were given doxycycline tablets orally and lactobacillus capsule（Ding Jun Sheng）via vagina for 10 days,while the 127 subjects in control group were given doxycycline tablets alone.The incidence rates of VVC during treatment and drug withdrawal phase,the cure rate of Uu 2weeks after drug withdrawal and recurrence rate of Uu within 3months after drug withdrawal were observed.Results The cure rate of Uu 2weeks after drug withdrawal in the observation group was higher than that in control group（88.0% vs 77.2%,P=0.035）,and the incidence rates of VVC during treatment and drug withdrawal phase in observation group were notably lower（8.0% vs 18.9%,P=0.019）.But there was no significant difference in recurrence rate within 3 months after drug withdrawal between the two groups（8.9% vs 16.1%,P〉0.05）.Conclusion Lactobacillus supplementation via vagina during antibiotic treatment of Uu infection is beneficial for the improvement of cure rate of Uu and prevention of VVC.