13933例妇科门诊患者人乳头瘤病毒感染状况分析

Human papilloma virus infection situation in 13 933 gynecological outpatients

目的探讨河北医科大学第四医院妇科门诊患者人乳头瘤病毒(HPV)感染情况及型别分布情况,为预防HPV感染和宫颈癌防治提供依据。方法采用核酸分子快速导流杂交技术对13 933例妇科门诊患者的宫颈细胞标本进行21种HPV亚型的基因检测,不同年龄组HPV感染率比较采用卡方检验。结果 13933例受检者中,HPV感染5 979例,感染率为42.9%。共计检出21种亚型,9 023例次HPV感染,其中HPV高危型7 823例次占86.7%,感染前三位分别为HPV-16、HPV-52、HPV-58;HPV低危型1 200例次占13.3%,感染前三位分别为HPV-CP8304、HPV-11、HPV-6;17~25岁和≥56岁年龄组HPV感染率相对较高,与其他年龄组比较差异有统计学意义。结论妇科门诊患者HPV感染率较高,且以高危型HPV感染为主,其中最常见的感染亚型是HPV-16、HPV-52、HPV-58。不同年龄组HPV感染率差异有统计学意义,17~25岁和≥56岁年龄组HPV感染率相对较高。

Objective To investigate the infection situation and gene subtype distribution of human papilloma virus（HPV）in gynecological outpatients in our hospital and provide basic data for prophylaxis and treatment of cervical cancer.Methods The specimens of cervical cells from 13 933 cases were tested for 21 subtypes of HPV genes using PCR and membrane hybridization technique.The rates of HPV infections in different age groups were compared by using chi-square test.Results A total of 5 979 HPV positive samples were found and the positive rate was 42.9%.HPV-16,HPV-52 and HPV-58 were the top three subtypes.The infection rates in 17-25 years old and over 56 years old groups were significantly higher than those in the other groups.Conclusion HPV infection rate is high in gynecological outpatients.HPV infection rates have statistical difference in different age groups,and women at age of 17-25 years and over 56 years are the high risk population of HPV infection.