阿托伐他汀联合阿司匹林治疗高血压伴发动脉粥样硬化的效果观察

Observation on Effect of Atorvastatin and Aspirin in Treatment of Hypertension with Atherosclerosis

目的探讨阿托伐他汀联合阿司匹林治疗高血压伴发动脉粥样硬化的效果。方法研究对象该院92例高血压伴动脉粥样硬化患者,收治时间为2016年6月—2017年6月间。通过电脑随机分组的方式,平分为两组,即常规组(n=46)与研究组(n=46)。常规组应用阿司匹林进行治疗,研究组应用阿托伐他汀联合阿司匹林进行治疗,统计分析两组临床治疗效果。结果①治疗后,研究组总有效率高达93.48%,常规组总有效率高达78.26%,组间疗效比较,差异有统计学意义(P<0.05);②治疗后,研究组血脂指标如总胆固醇(1.1±0.2)mmol/L、三酰甘油(3.1±0.3)mmol/L、LDL-C水平(2.5±1.3)mmol/L低于常规组(1.8±0.3)mmol/L、(4.2±0.6)mmol/L、(3.4±1.5)mmol/L,HDL-C水平(1.8±1.3)mmol/L高于常规组(1.4±0.6)mmol/L(P<0.05),血压指标如舒张压(80.3±3.5)mm Hg、收缩压(126.7±3.7)mm Hg等低于常规组(96.1±4.4)、(136.7±3.4)mm Hg(P<0.05);③对比两组斑块面积,研究组(18.3±2.5)mm^2小于常规组(22.5±2.6)mm^2,差异有统计学意义(P<0.05)。结论临床治疗高血压伴动脉粥样硬化,应用阿托伐他汀、阿司匹林联合治疗,疗效显著,可帮助患者减低血压,改善血脂,缩小斑块面积,值得临床重视。

Objective To study the effect of atorvastatin and aspirin in treatment of hypertension with atherosclerosis.Methods 92 cases of patients with hypertension with atherosclerosis in our hospital from June 2016 to June 2017 were selected as the research objects and randomly divided into two groups with 46 cases in each, the routine group adopted the aspirin, while the research group adopted the atorvastatin and aspirin, and the clinical treatment effect was compared between the two groups. Results After treatment, the total treatment effective rate in the research group and in the routine group was respectively 93.48% and 78.26%, and the difference was statistically significant（P〈0.05）, after treatment, the blood liquid indexes such as total cholesterol, triacylglycerol and LDL-C levels in the research group were lower than those in the routine group, [（1.1 ±0.2）mmol/L,（3.1 ±0.3）mmol/L,（2.5 ±1.3）mmol/L vs（1.8 ±0.3）mmol/L,（4.2±0.6）mmol/L,（3.4±1.5）mmol/L], and the HDL-C level was higher than that in the routine group[（1.8±1.3）mmol/L vs（1.4±0.6）mmol/L]（P〈0.05）, and the dualistic pressure and systolic pressure were lower than those in the routine group,[（80.3±3.5）mm Hg,（126.7±3.7）mm Hg vs（96.1±4.4）mm Hg,（136.7 ±3.4）mm Hg]（P 〈0.05）, and the plaque area in the research group was smaller than that in the routine group[（18.3±2.5）mm^2 vs（22.5±2.6） mm^2], and the difference was statistically significant（P〈0.05）. Conclusion The curative effect of atorvastatin and aspirin in clinical treatment of hypertension with atherosclerosis is obvious, which can help reduce the blood pressure, improve blood liquid and shorten the plaque area, and it is worth clinical attention.