老年糖尿病合并肝硬化患者白蛋白相关生化指标检验的临床意义研究

Clinical Significance of Serum Albumin Related Biochemical Indexes in Elderly Patients of Diabetes Mellitus Complicated with Liver Cirrhosis

目的探讨老年糖尿病合并肝硬化患者白蛋白相关生化指标检验的临床意义。方法选取2016年1月—2017年3月于该院就诊的老年糖尿病合并肝硬化患者122例,给予相应治疗,分别于干预后1、2、3周检测患者血清中ALB、PA水平,同时评估糖尿病合并肝硬化患者治疗效果。采用溴甲酚氯法检测ALB,免疫比浊法检测PA。结果干预后1周有效者18例,无效者104例;第2周有效者40例,无效者82例;第3周有效者85例,无效者37例。干预前及干预后1、2、3周老年糖尿病合并肝硬化患者ALB均差异无统计学意义(P>0.05)。和干预前及干预后1周相比,干预后2、3周PA显著上升(P<0.05)。结论检测老年糖尿病合并肝硬化患者ALB、PA水平有助于评估患者治疗疗效。

Objective This paper tries to investigate the clinical significance of serum albumin related biochemical indexes in elderly patients with diabetes mellitus complicated with liver cirrhosis. Methods 122 cases of elderly patients with dia-betes mellitus complicated with liver cirrhosis treated in this hospital from January 2016 to March 2017 were selected and were given corresponding treatment, the ALB, the levels of serum PA detection respectively in one week, 2 weeks and 3 weeks after treatment and the curative effect were evaluated. ALB was detected by bromine chloride, and PA was detected by turbidimetric immunoassay. Results One week after treatment, 18 cases were effective, 104 cases were invalid; 40 cases were effective, 82 cases were invalid in second week; 85 cases were effective, 37 cases were invalid in third weeks. There was no significant difference in ALB between before intervention and one, two and three weeks after treatment （ P 〉0.05）. Compared with that before intervention and one week after treatment, PA increased significantly in the second and third week （ P〈0.05）. Conclusion The detection of ALB and PA levels in elderly patients with diabetes mellitus complicated with cirrhosis is helpful to evaluate the therapeutic efficacy of patients.