酪氨酸的化学修饰及其光降解性能

Chemical Modification of Tyrosine and Its Photo Degradation Property

为提升酪氨酸的光稳定性能,首先合成了含伯胺基的苯并三唑结构化合物,再基于三组份Mannich反应将伯胺基苯并三唑结构修饰到酪氨酸分子上,采用紫外、红外、质谱测试表征了合成化合物和修饰酪氨酸产物的结构,并对其紫外光降解性能进行了测试.结果表明,合成的伯胺基苯并三唑结构化合物系目标产物,基于Mannich反应可实现苯并三唑结构对酪氨酸分子的化学修饰,经紫外线光照10h,酪氨酸光降解率达61.03%,而修饰酪氨酸产物的光降解率为26.55%,修饰后酪氨酸的光稳定性能得到大幅提升.

In order to enhance the photostability of tyrosine, one benzotriazole compound containingpri- mary amine group was synthesized at firsthand then, modification of tyrosine by benzotriazole structure from the synthetic compound based on three component Mannich reaction was conducted.U V ,R and MS methods were used to characterize the synthetic compound and modified tyrosine product？and light deg-radation of these two products were tested at the same time.The results showed that the benzotriazolecompound containing primary amine group was the target product？and the chemical modification of tyro-sine molecule by benzotriazole structure based on Mannich reaction can be achieved.The degradation rate of tyrosine and modified tyrosine was 61.03% and 26.55% respectively after exposure to UV radiation for 10 h. So the photostability of tyrosine will be improved significantly after modification using thismethod.