血栓弹力图在肺癌患者凝血功能异常中的应用

Study on the application of thromboelastography in assessing coagulation status in patients with carcinoma of the lungs

目的研究血栓弹力图(TEG)在肺癌患者凝血功能异常中的意义。方法对本院确诊为肺癌的273例患者在2015年5月-2016年5月住院治疗期间,进行TEG、凝血4项及静脉血管超声检查,根据有无血栓形成分为血栓组、无血栓组;正常体检人员18名设为对照组,并比较3组凝血指标的差异情况。结果 TEG检测显示R值降低,血栓组与无血栓组、对照组比较,差异均有统计学意义(P<0.05);其他检测项目比较无统计学意义(P>0.05)。结论肺癌患者的TEG检测中R值降低,显示其血液处于高凝状态,有并发血栓的风险。

Objective To investigate the role of thromboelastography（TEG） in assessing coagulation status in patients with carcinoma of the lungs.Methods TEG,routine coagulation tests and venous Doppler ultrasound were done to detect the coagulation status in 273 patients who were diagnosed with lung cancer in Henan Tumor Hospital from May 2015 to May2016.The patients were divided into two groups： group 1 was diagnosed with deep vein thrombosis and group 2 was not diagnosed with thrombosis,in addition to a control group consisting of non-lung cancer patients with normal lung function.The detection results were compared among the three groups.Results The difference of R values between group 1 and group 2,and group 1 and control demonstrated significant differences（P〈 0.05）.No statistically significant difference was found in the other test parameters among the three groups（P〉0.05）.Conclusion The R value in TEG may indicate hypercoagulability and predict the high risk for deep vein thrombosis formation in patients with lung cancer.