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莫西沙星侧链合成方法改进 被引量：5

The Improved Synthesis of Moxifloxacin Side Chain
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摘要 以2,3-吡啶二羧酸为原料,经过环合、催化氢化、拆分、消旋、化学还原、脱苄基等反应步骤,合成得到莫西沙星侧链.该合成线路比现有常规合成路线污染小,收率较高. Moxifloxacin side chain is synthesized from 2,3-pyridinedicarboxylic acid as raw material,through cyclization,catalytic hydrogenation,resolution,racemization chemical reduction,debenzylation. Compared with the existed synthesis routes,the improved synthesis has advantages of small pollution and high yield.
作者 喻理德 徐其雄 王星
机构地区 江西中医药大学药物设计合成中心 南昌森腾医药生物科技有限公司
出处 《江西师范大学学报（自然科学版）》 CAS 北大核心 2017年第5期505-507,共3页 Journal of Jiangxi Normal University(Natural Science Edition)
基金 国家自然科学基金(81360629) 江西中医药大学自然科学基金(2012ZR030)资助项目
关键词 莫西沙星侧链 合成方法 改进 moxifloxacin side chain synthesis improvement
分类号 TQ463.53 [化学工程—制药化工]
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  • 1Petersen U, Krebs A, Schenke T, etal. Preparation of (diazabicyclononyl)quinolones and related compound as antibacterials[P]. EP550903, 1993-07-14.
  • 2Takemura M, Kimura Y, Matsuhashi N. Bicyclic amine derivatives of quinolones as single stereoisomers, useful as antimicrobials [P]. EP603887, 1994-06-29.
  • 3Takagi N,Fubasami H, Matsukubo H. ( 6,7-Substituted-8- alkoxy-1 cyclopropyl-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid bis(acyloxy-o)borates and the salts thereof, and methods for their manufacture [P]. EP464823, 1992-01-08.
  • 4Iwata M, Kimura T, Fujiwara Y, et al. Preparation of alkoxyfluoroquinolonecarboxylic acid derivatives as medical bactericides [P].EP241206, 1987-10-14.
  • 5Arora A, Scholar E M. Role of tyrosine kinase inhibitors in cancertherapy [ J ]. J Pharmacol Exp Ther,2005,315 ( 3 ) : 971-979.
  • 6Sarker D, Molife R, Evans T R J, et al. A phase I pharmaco-" kinetic and pharmacodynamic study of TKI258, an ora, 1 muhitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors [ J ]. Clin Cancer Res, 2008, 14(7) :2075-2081.
  • 7John B Hynes, Alpana Pathak, Constantina H Panes, et al. Direct synthesis of 2,4-diaminoquinazolines from 2-iluoro- benzonitriies [ J ]. Journal of Heterocyclic Chemistry, 1988,25 (4) :1173-1177.
  • 8Dieter H Klaubert, John H Sellstedt, Charles J Guinosso, et al. N-(Aminophenyl )oxamic acids and esters as potent, orally active antiallergy agents [ J ]. ：Joumal of Medicinal Chemistry,1981,24(6) :742-748.
  • 9Calvin G, Harwood E, Ryckman D, et al. Methods for syn- thesizing heterocyclic compounds : WO, 2006125130 [ P ]. 2006-11-23.
  • 10William R Antonios-McCrea, Kelly A Frazier, Elisa M Jazan, et al. LHMDS mediated tandem acylation-cycliza- tion of 2-aminobenzenecarbonitriles with 2-benzymidazol- 2-yl acetates:a short and efficient route to the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones [ J ]. Tetrahedron Letters,2006,47 : 657 -660.

共引文献5

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江西师范大学学报（自然科学版）
2017年 第5期

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