注射用盐酸丙帕他莫合理调配方案研究

Rational Dispensation of Propacetamol Hydrochloride for Injection

目的考察注射用盐酸丙帕他莫的合理调配方法,保证调配成品安全有效。方法将盐酸丙帕他莫按体积比1∶50稀释,分别配伍0.9%氯化钠注射液、5%葡萄糖氯化钠注射液、10%葡萄糖注射液、5%葡萄糖注射液和转化糖注射液,以及与0.9%氯化钠注射液按体积比1∶100稀释配伍,观察其配伍后的外观性状,检测pH、不溶性微粒及盐酸丙帕他莫含量变化。结果选用0.9%氯化钠注射液作为溶剂,按照1∶50体积比稀释配伍后,成品溶液在2 h内稳定性较好,盐酸丙帕他莫含量变化小,pH、不溶性微粒均符合规定。结论临床应首选0.9%氯化钠注射液作为注射用盐酸丙帕他莫的溶剂,配伍稀释体积比为1∶50,且调配后应在短时间内尽快使用。

Objective To investigate the rational dispensation method of Propacetamol Hydrochloride for Injection,and to ensure the safe-ty and effectiveness of deployment of the finished product. Methods The propacetamol hydrochloride was diluted by volume ratio of 1 ： 50,which were compatible with 0.9% Sodium Chloride Injection,5% Glucose and Sodium Chloride Injection, 10% Glucose Injection, 5% Glucose Injection and Invert Sugar Injection,and 0.9% Sodium Chloride Injection diluted by the volume ratio of 1 ： 100. The mor-phological characteristics of the mixture were observed,and the pH,insoluble particles and content change of propacetamol hydrochloride were measured. Results 0.9% Sodium Chloride Injection was chosen as solvent, in accordance with the volume ratio of 1 ： 50 diluted solution of the drug compatibility and good stability in 2 h. There was little change in the content of propacetamol hydrochloride, and the pH and insoluble particles met the requirements. Conclusion 0. 9% Sodium Chloride Injection should be used as preferred solvent with dilution volume ratio of 1 ： 50 for Propacetamol Hydrochloride for Injection and it should be used in a short time after configured.