临床药师干预特殊使用级抗菌药物应用效果评价

Effect Evaluation of Clinical Pharmacists' Pharmaceutical Intervention on Application of Antibiotics for Special Use

目的评价临床药师对特殊使用级抗菌药物临床应用的干预效果。方法分别抽取医院2015年1月至6月(干预前)和2016年1月至6月(干预后)应用特殊使用级抗菌药物的住院病历各200份(剔除重症监护室和小儿内科病历),比较该类药物的使用率和人均费用等指标,并对其临床应用合理性、不良反应发生情况、疾病转归情况、预防用药情况进行统计和分析。结果干预后,特殊使用级抗菌药物的临床应用合理性、疾病转归情况较干预前有明显改善,使用率由12.67%降至7.75%,人均费用由307.94元降至178.60元,预防用药率由40.50%降至10.00%(P<0.05)。结论临床药师对特殊使用级抗菌药物实施药学干预,可显著降低各项应用指标,干预效果显著,可为临床安全、有效、经济、合理地应用该类药物发挥积极作用。

Objective To evaluate the intervention effect of clinical pharmacists on the clinical application of antibiotics for special use.Methods Totally 200 cases of clinical data were collected from all inpatients with antibiotics for special use from January to June in 2015(before intervention) and from January to June in 2016(after intervention),respectively(elimination of medical records in ICU and Department of Pediatric Internal Medicine).The utilization rate and per capita cost of the drugs were compared,and the clinical rational drug use,the occurrence of adverse drug reactions,the prognosis of the disease and the preventive medication were statistically analyzed.Results After intervention,the clinical application rationality and disease prognosis of antibiotics for special use were significantly improved compared with those before intervention,the utilization rate decreased from 12.67% to 7.75%,the per capita cost decreased from 307.94 Yuan to 178.60 Yuan,and the rate of preventive medication decreased from 40.50% to 10.00%(P < 0.05).Conclusion The clinical pharmacists' intervention on the application of antibiotics for special use can significantly reduce the indexes of application,it has significantly intervention effect,which can play a positive role for the safe,effective,economical and rational use of the drugs in clinic.