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格拉司琼透皮贴治疗化疗所致恶心呕吐的研究进展 被引量:1

Progress in researches for granisetron transdermal delivery system in controlling chemotherapy-induced nausea and vomiting
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摘要 化疗所致恶心呕吐(CINV)是肿瘤患者化疗过程中最常见的不良反应之一。严重的恶心呕吐会导致水电解质紊乱和营养不良,降低患者化疗依从性并影响其生活质量。5-羟色胺3受体(5-HT_3)拮抗剂是治疗CINV的一线用药,国内目前上市的主要是其静脉制剂或口服制剂。格拉司琼透皮贴剂是首个获美国FDA批准上市的且至今唯一的5-HT_3受体拮抗剂透皮贴,用于控制中、高等程度致吐性CINV。在国内外多项临床试验中格拉司琼透皮贴剂显示出不逊于格拉司琼口服制剂的临床疗效,且能平稳控制CINV长达7天。本文将对其药代动力学和临床应用两大方面的研究进展进行综述。 gress in researches for granisetron transdermal delivery system in controlling chemotherapy-induced nausea and vomiting
出处 《临床肿瘤学杂志》 CAS 2017年第10期945-949,共5页 Chinese Clinical Oncology
基金 国家自然科学基金资助项目(81572961)
关键词 化疗所致恶心呕吐 格拉司琼透皮贴剂 5-羟色胺3受体拮抗剂 药代动力学 临床应用 Chemotherapy-induced nausea and vomiting Granisetron transdermal system 5-hydroxytryptamine 3 receptor antagonist Pharmacokinetics Clinical application
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