疏肝解郁方治疗乳腺增生病肝郁气滞证临床研究

Clinical Observation of Shugan Jieyu Prescription in Treating HMG with Qi Stagnation due to Liver Depression

目的:观察疏肝解郁方治疗乳腺增生病(HMG)肝郁气滞证的临床疗效。方法:将132例HMG肝郁气滞证患者随机分为对照组和观察组各66例。对照组给予三苯氧胺治疗,观察组给予疏肝解郁方治疗。评估2组临床疗效,观察患者治疗前后相关指标的变化。结果:观察组治疗总有效率93.94%,高于对照组的77.27%(P<0.05)。治疗后,2组血清孕酮(P)、睾酮(T)和卵泡刺激素(FSH)水平均较治疗前升高(P<0.05),血清催乳素(PRL)、雌二醇(E2)及黄体生成素(LH)水平均较治疗前降低(P<0.05);观察组血清P、T和FSH水平均较对照组上升更明显(P<0.05),血清PRL、E2及LH水平均较对照组下降更明显(P<0.05)。治疗后,2组全血黏度、血浆黏度、红细胞比容水平均较治疗前下降(P<0.05);观察组的3项血液流变学指标水平均较对照组下降更明显(P<0.05)。治疗后,2组VAS评分均较治疗前下降(P<0.05),肿块最大直径均较治疗前缩短(P<0.05);观察组的VAS评分比对照组下降更明显(P<0.05),肿块最大直径比对照组缩短更明显(P<0.05)。结论:疏肝解郁方治疗HMG肝郁气滞证效果显著,能改善患者的症状、体征,调节性激素紊乱状况。

Adjective： To observe the clinical effect of Shugan Jieyu prescription in treating hyperplasia of mammary glands （HMG） with qi stagnation due to liver depression. Methods：Selected 132 cases of HMG patients with qi stagnation due to liver depression, and divided them into the control group and the observation group being 66 cases in each. The control group was given Tamoxifen, while the observation group was given Shugan Jieyu prescription. Evaluated clinical effect of the two groups, and observed changes of the relavant indexes before and after treatment. Results= The total effective was 93.94% in the obseravtion group and was 77.27% in the control group. After treatment, levels of serum progesterone（P）, testosterone （T） and follicle stimulating hormone（FSH） of the two groups were higher than those before treatment（P〈 0.05）, levels of serum prolactin（PRL）, estradiol（E2） and luteinizing hormone（LH） of the two groups were lower than those before treatment（P〈 0.05）. After treatment, increase of levels of serum P, T and FSH and the decrease of levels of serum PRL, E2 and LH in the observation group were more obvious than those in the control group （P 〈0.05）. After treatment, whole blood contrast viscosity, plasma viscosity and hematocrit in the two groups were all lower than those before treatment（P〈 0.05）; decrease of the three hemorheology indexes of the observation group was more significant than that of the control group（P〈 0.05）. After treatment, VAS scores and maximum diameter of lump in the two groups were lower or shorter than those before treatment （P 〈 0.05）; and the decrease of VAS scores and maximum diameter of lump of the observation group was more significant than that in the control group（P〈0.05）. Conclusion： Shugan Jieyu prescription has significant effect in treating HMG with qi stagnation due to liver depression, which can improve symptoms and body sign, regulate hormone disorders.